ArticleInternational journal of molecular sciences2026
Effects of Probiotics and Vitamin D Deficiency Correction on Clinical, Inflammatory, Metabolic, and Microbiota Profiles in Older Adults with Oral Lichen Planus: A Multi-Omics Study.
Paola Zanetta, Matteo Calgaro, Marta Mellai, Alessia Vignoli, Monica Marotta, Nicola Vitulo, Leonardo Tenori, Marcello Manfredi, Elettra Barberis, Mario Migliario and 7 more
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
17 authors.
Paola ZanettaLaboratory of Applied Microbiology, Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), Department of Health Sciences (DiSS), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.ORCID 0000-0001-8547-3090 Matteo CalgaroDepartment of Biotechnology, University of Verona, Strada le Grazie, 15, 37134 Verona, Italy.ORCID 0000-0002-3056-518X Marta MellaiIntegrative Genomics Core Facility, Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), Department of Health Sciences (DiSS), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.
Alessia VignoliDepartment of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0003-4038-6596 Monica MarottaOdontostomatology Unit, Azienda Ospedaliero Universitaria (AOU) "Maggiore della Carita", 28100 Novara, Italy.
Nicola VituloDepartment of Biotechnology, University of Verona, Strada le Grazie, 15, 37134 Verona, Italy.ORCID 0000-0002-9571-0747 Leonardo TenoriDepartment of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 3-13, Sesto Fiorentino, 50019 Florence, Italy.ORCID 0000-0001-6438-059X Marcello ManfrediBiological Mass Spectrometry, Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), Department of Translational Medicine (DiMeT), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.ORCID 0000-0003-0632-5618 Elettra BarberisCenter for Translational Research on Allergic and Autoimmune Diseases (CAAD), Department of Sciences and Technological Innovation (DISIT), Università del Piemonte Orientale (UPO), 15121 Alessandria, Italy.
Mario MigliarioOdontostomatology Unit, Azienda Ospedaliero Universitaria (AOU) "Maggiore della Carita", 28100 Novara, Italy.ORCID 0000-0003-1627-4164 Marta ArmariLaboratory of Applied Microbiology, Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), Department of Health Sciences (DiSS), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.ORCID 0009-0000-1243-1615 Valeria CaneparoProtein Technologies Core Facility, Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), Department of Translational Medicine (DiMeT), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.ORCID 0000-0002-8210-3235 Diletta Francesca SquarzantiLaboratory of Applied Microbiology, Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), Department of Health Sciences (DiSS), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.ORCID 0000-0001-8090-7718 Marta AllesinaIntegrative Genomics Core Facility, Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), Department of Health Sciences (DiSS), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.
Barbara AzzimontiLaboratory of Applied Microbiology, Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), Department of Health Sciences (DiSS), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy.ORCID 0000-0001-6364-6595 Funding
European Union CUP B83C22004800006University of Piemonte Orientale Amedeo Avogadro Fondi di Ricerca di Ateneo (FAR-2017) provided by UPO
6 · The paper itselfAbstract
Oral lichen planus (OLP) is a chronic inflammatory oral disease associated with immune dysregulation and malignant transformation risk. Vitamin D and probiotics may modulate immune and microbial pathways involved in OLP. In this study, we evaluated their effects on clinical outcomes and multi-omics profiles in 25 adult OLP patients (median age: 68 years). Vitamin D-deficient patients received 2000 IU/day vitamin D3, and all participants received a probiotic blend (
Indexed as
Lichen Planus, OralMicrobiotaProbioticsVitamin D DeficiencyAgedFecesFemaleHumansMaleMetabolomeMetabolomicsMiddle AgedMultiomicsSaliva16S RNA sequencingcytokinesmetabolomicsoral and gut microbiotaoral lichen planus (OLP)probioticsproteomicsvitamin D
Identifiers
PMID42589365
PMCPMC13467221
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