Direct Effects of 308-nm Excimer Light on Keratinocyte Proliferation and Differentiation in Human Organ-Cultured Skin.

Ayaka Okazaki, Hisayoshi Imanishi, Hiroyuki Kunimoto, Daisuke Tsuruta

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ayaka OkazakiDepartment of Dermatology, Graduate School of Medicine, Osaka City University, Osaka 5458585, Japan.ORCID 0000-0002-6475-0586

Hisayoshi ImanishiDepartment of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka 5458585, Japan.ORCID 0000-0001-6930-5521

Hiroyuki KunimotoDepartment of Immunology, Graduate School of Medicine, Osaka Metropolitan University, Osaka 5458585, Japan.ORCID 0009-0004-6925-089X

Daisuke TsurutaDepartment of Dermatology, Graduate School of Medicine, Osaka Metropolitan University, Osaka 5458585, Japan.

Funding

departmental research funds.

6 · The paper itself

Abstract

Targeted phototherapy using 308-nm excimer light (EL-308) is widely employed to treat localized skin diseases, such as psoriasis and vitiligo. Although its immunomodulatory effects are well established, tissue-level epidermal responses to EL-308 in human skin explants have not been fully characterized in a controlled ex vivo setting. Therefore, the present study examined dose- and time-dependent changes in keratinocyte proliferation, apoptosis, and differentiation markers in a human organ-cultured skin model without systemic immune inputs (i.e., without circulation-dependent immune-cell recruitment). Human organ-cultured skin samples were irradiated with EL-308 at 300, 400, or 600 mJ/cm

Indexed as

Cell DifferentiationCell ProliferationKeratinocytesLasers, ExcimerSkinApoptosisHumansKi-67 AntigenOrgan Culture TechniquesKi-67 Antigen308-nm excimer lightapoptosishuman organ-cultured skinkeratinocyteMAPK signaling pathwayproliferationRNA sequencing

Identifiers

PMID42589355

DOI10.3390/ijms27156698

PMCPMC13467002

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.