ArticleInternational journal of molecular sciences2026
First-in-Class Immuno-Oncology Drug APG157DS Repolarizes Innate Immune Cells and Induces Durable Remission in a Syngeneic Glioblastoma Model.
Shubhasmita Mohapatra, Adrian Guerrero, Neha Rahman, Stefan Markovic, Lauren O'Donnell, Youssef Zaim Wadghiri, Khondoker Takia Zaman, Luis Avila, Parag Mehta, Probal Banerjee
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Shubhasmita MohapatraDepartment of Chemistry, The College of Staten Island (CUNY), Staten Island, NY 10314, USA.
Adrian GuerreroDoctoral Program in Biochemistry, The College of Staten Island (CUNY), New York, NY 10314, USA.ORCID 0009-0002-8864-489X Neha RahmanDepartment of Radiology, Bernard and Irene Schwartz Center for Biomedical Imaging & Center for Advanced Imaging Innovation and Research and Preclinical Imaging, Division for Advanced Research Technologies, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0009-0009-4316-1369 Stefan MarkovicDepartment of Radiology, Bernard and Irene Schwartz Center for Biomedical Imaging & Center for Advanced Imaging Innovation and Research and Preclinical Imaging, Division for Advanced Research Technologies, New York University Grossman School of Medicine, New York, NY 10016, USA.
Lauren O'DonnellDepartment of Radiology, Bernard and Irene Schwartz Center for Biomedical Imaging & Center for Advanced Imaging Innovation and Research and Preclinical Imaging, Division for Advanced Research Technologies, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-5669-7893 Youssef Zaim WadghiriDepartment of Radiology, Bernard and Irene Schwartz Center for Biomedical Imaging & Center for Advanced Imaging Innovation and Research and Preclinical Imaging, Division for Advanced Research Technologies, New York University Grossman School of Medicine, New York, NY 10016, USA.
Khondoker Takia ZamanDoctoral Program in Biochemistry, The College of Staten Island (CUNY), New York, NY 10314, USA.
Luis AvilaAveta Biomics, Inc., 110 Great Road, Suite 302, Bedford, MA 01730, USA.
Parag MehtaAveta Biomics, Inc., 110 Great Road, Suite 302, Bedford, MA 01730, USA.
Probal BanerjeeDepartment of Chemistry, The College of Staten Island (CUNY), Staten Island, NY 10314, USA.ORCID 0000-0001-9429-1010 Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1MTR&D 4: Revealing Microstructure: Biophysical modeling and validation for discovery and clinical careP41EB017183 · NIBIB · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Daniel K Sodickson · 2014 to 2026
$19.3M7T Small Animal MRI Scanner Replacement for Translational Imaging ResourceS10OD018337 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BOADA, FERNANDO E · 2014 to 2014
$2.0MAveta Biomics, Inc. Award 55NCI NIH HHS P30 CA016087NIBIB NIH HHS P41 EB017183NIH HHS S10 OD018337
6 · The paper itselfAbstract
APG157DS is a multi-component investigational drug which is currently the subject of multiple cancer trials. It has shown promising efficacy in patients with head and neck cancer. We report its immuno-modulatory effect in a syngeneic mouse model of glioblastoma (GBM). Long-term treatment with APG157DS led to durable tumor remission in 50% of mice, while all vehicle-treated mice reached humane endpoints within 42 days. Mechanistically, the drug induced selective repolarization of tumor-associated macrophages (TAMs) from an immunosuppressive Arg1
Indexed as
Brain NeoplasmsGlioblastomaImmunity, InnateAnimalsCell Line, TumorDisease Models, AnimalHumansKiller Cells, NaturalMacrophagesMiceTumor-Associated MacrophagesVascular Endothelial Growth Factor AVascular Endothelial Growth Factor AAPG157DSArg1/iNOScurcuminglioblastomaM2/M1tumor-associated microglia and macrophages (TAMs)
Identifiers
PMID42589344
PMCPMC13466085
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