Lipid Challenge Reveals Amplified Apolipoprotein Responses with Preserved Temporal Pattern in Polyendocrine Metabolic Ovarian Syndrome: An Exploratory Study.

Ebrahim Rajab, Abu Saleh Md Moin, Manjula Nandakumar, Thozhukat Sathyapalan, Alexandra E Butler, Stephen L Atkin

Abstract readRandomized Controlled Trial

In one paragraph

Trial report in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ebrahim RajabRoyal College of Surgeons of Ireland, Medical University of Bahrain, Busaiteen 228, Bahrain.ORCID 0000-0002-0085-5338

Abu Saleh Md MoinRoyal College of Surgeons of Ireland, Medical University of Bahrain, Busaiteen 228, Bahrain.

Manjula NandakumarRoyal College of Surgeons of Ireland, Medical University of Bahrain, Busaiteen 228, Bahrain.

Thozhukat SathyapalanAcademic Endocrinology, Diabetes and Metabolism, Hull York Medical School, Hull HU6 7RX, UK.ORCID 0000-0003-3544-2231

Alexandra E ButlerRoyal College of Surgeons of Ireland, Medical University of Bahrain, Busaiteen 228, Bahrain.ORCID 0000-0002-5762-3917

Stephen L AtkinRoyal College of Surgeons of Ireland, Medical University of Bahrain, Busaiteen 228, Bahrain.ORCID 0000-0002-5887-7257

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute elevation in circulating lipids induces reversible insulin resistance and alters triglyceride-rich lipoprotein flux. Whether insulin-regulated remodelling of high-density lipoprotein (HDL)-associated apolipoproteins is altered during defined lipid stress in women with polyendocrine metabolic ovarian syndrome (PMOS) remains unclear. In this exploratory, randomized, cross-over study, 10 healthy women and 12 women with PMOS underwent 5-h saline or lipid infusion, with a hyperinsulinemic-euglycemic clamp commencing at 180 min. Plasma proteomics were performed at baseline, 180 min and 300 min using linear modelling (limma). Lipid infusion induced the coordinated suppression of ApoA1 and ApoE isoforms at 180 min in both groups (FDR-adjusted

Indexed as

ApolipoproteinsLipidsMetabolic SyndromeAdultApolipoprotein A-IApolipoproteins ECross-Over StudiesFemaleGlucose Clamp TechniqueHumansInsulinInsulin ResistanceLipid MetabolismLipoproteins, HDLProteomicsAPOA1 protein, humanApolipoprotein A-IApolipoproteinsApolipoproteins EInsulinLipidsLipoproteins, HDLapolipoproteinsinsulin resistancelipid metabolismmetabolic flexibilitypolyendocrine metabolic ovarian syndromeproteomics

Identifiers

PMID42589314

DOI10.3390/ijms27156656

PMCPMC13465879

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.