Evidence map›Paper›PMID 42589292›Full record

ArticleInternational journal of molecular sciences2026

Differential Regulation of Neutrophil Elastase Release vs. NET Generation After Cardiopulmonary Bypass.

Erin Tresselt Murray, Jessica S Hook, Parth Patel, Lihua Xie, Jessica Moreland

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erin Tresselt MurrayDivision of Critical Care Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA.ORCID 0000-0003-1565-9249
Jessica S HookDepartment of Pediatrics, Children's Medical Center Dallas, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Parth PatelDepartment of Pediatrics, Children's Medical Center Dallas, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lihua XieDepartment of Pediatrics, Children's Medical Center Dallas, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jessica MorelandDepartment of Pediatrics, Children's Medical Center Dallas, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-8487-9494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiopulmonary bypass (CPB) during heart surgery provokes an inflammatory response that can cause post-operative organ injury, yet how CPB shapes key neutrophil effector programs is unclear. We investigated whether CPB differentially regulates neutrophil degranulation versus neutrophil extracellular trap (NET) formation and whether pre-operative neutrophil phenotypes associate with organ dysfunction. In a prospective cohort (

Indexed as

Cardiopulmonary BypassExtracellular TrapsLeukocyte ElastaseNeutrophilsCell DegranulationChild, PreschoolFemaleHumansInfantInfant, NewbornMaleNeutrophil ActivationProspective StudiesLeukocyte Elastasecardiopulmonary bypassinflammationneutrophilneutrophil extracellular traporgan injury

Identifiers

PMID42589292
PMCPMC13467006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.