The Preparation of Hypoallergenic Goat Milk Protein Hydrolysates via Targeted Hydrolysis of Cross-Reactive Linear Epitopes Between Cow and Goat Milk.

Fengyi Wang, Wenxuan Zhao, Yanjun Cong

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

3 authors.

Fengyi WangBeijing Engineering and Technology Research Center of Food Additives, College of Food and Health, Beijing Technology and Business University, Beijing 100048, China.

Wenxuan ZhaoBeijing Engineering and Technology Research Center of Food Additives, College of Food and Health, Beijing Technology and Business University, Beijing 100048, China.

Yanjun CongBeijing Engineering and Technology Research Center of Food Additives, College of Food and Health, Beijing Technology and Business University, Beijing 100048, China.ORCID 0000-0003-1473-2440

Funding

Dairy Science and Technology Innovation Fund CDIAKCJJ-TP-2024-007National Science and Technology Major Project of China 2019YFC1605002

6 · The paper itself

Abstract

Cow's milk allergy (CMA) is the most common food allergy in infants. Goat milk exhibits relatively low allergenicity and is widely regarded as a potential substitute for cow milk. However, the high sequence homology between cow and goat milk proteins may trigger cross-reactivity, significantly restricting the practical application of goat milk. This study aims to disrupt cross-linear epitopes of cow and goat milk proteins through enzymatic hydrolysis. We prepare hypoallergenic goat milk protein hydrolysates and systematically evaluate their desensitization effects. Bioinformatics methods were employed to predict the B-cell linear epitopes of six major allergens (α

Indexed as

AllergensEpitopesEpitopes, B-LymphocyteMilkMilk HypersensitivityMilk ProteinsProtein HydrolysatesAmino Acid SequenceAnimalsCaseinsCattleCross ReactionsGoatsHumansHydrolysisLactalbuminAllergensCaseinsEpitopesEpitopes, B-LymphocyteLactalbuminMilk ProteinsProtein Hydrolysatesallergenicitycow milk proteincross reactivityenzymatic hydrolysisgoat milk proteinlinear epitope

Identifiers

PMID42589261

DOI10.3390/ijms27156603

PMCPMC13465632

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.