ArticleInternational journal of molecular sciences2026
Cross-Omic Comparative Analysis Identifies Transcriptomic Signatures and Exploratory Gene Set-Level Signals in Sporadic Creutzfeldt-Jakob Disease.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sporadic Creutzfeldt-Jakob disease (sCJD) is a rapidly progressive fatal neurodegenerative disease whose basis of pathogenesis remains incompletely defined. Public datasets allow molecular changes to be compared across transcriptomic, post-transcriptional, and epigenomic layers, but comparisons are limited by differences in tissue source and platform. We performed a cross-omic comparative analysis of four sCJD case-control datasets spanning mRNA, miRNA, and DNA methylation layers. In this study, cross-omic refers to comparison of independently analyzed molecular datasets rather than joint multi-omic modeling of matched molecular layers from the same samples. Differential feature analysis, overrepresentation analysis, and gene set enrichment analysis were conducted within each layer. Reproducibility was evaluated across discovery and validation cohorts, followed by cross-layer comparison at the gene level and GO-BP gene set level. FDR-controlled overlap was treated as the primary analysis, whereas nominal
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