Evidence map›Paper›PMID 42589225›Full record

ArticleInternational journal of molecular sciences2026

Mutant-Selective Binding of

William D Lituma-González, Diksha Dinesh Kumar, Amogh V Arunprasad, Tanishque Verma, Shrutika Pillai, Fabian R Jimenez, Sasikumar J Mahalingam, Shanmugamurthy Lakshmanan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

William D Lituma-GonzálezDepartment of Integrative and Transdisciplinary Pharmacognosy, Siddha Vetha University, 211 Warren st, Newark, NJ 07103, USA.
Diksha Dinesh KumarDepartment of Integrative and Transdisciplinary Pharmacognosy, Siddha Vetha University, 211 Warren st, Newark, NJ 07103, USA.ORCID 0009-0000-1075-201X
Amogh V ArunprasadDepartment of Integrative and Transdisciplinary Pharmacognosy, Siddha Vetha University, 211 Warren st, Newark, NJ 07103, USA.
Tanishque VermaDepartment of Integrative and Transdisciplinary Pharmacognosy, Siddha Vetha University, 211 Warren st, Newark, NJ 07103, USA.ORCID 0000-0002-7504-6666
Shrutika PillaiDepartment of Neuroscience, University of Virginia, P.O. Box 400224, Charlottesville, VA 22904, USA.
Fabian R JimenezDepartment of Integrative and Transdisciplinary Pharmacognosy, Siddha Vetha University, 211 Warren st, Newark, NJ 07103, USA.ORCID 0000-0003-1385-7946
Sasikumar J MahalingamDepartment of Microbiology, Karpagam Academy of Higher Education, Coimbatore 641021, India.ORCID 0000-0003-1245-4109
Shanmugamurthy LakshmananDepartment of Integrative and Transdisciplinary Pharmacognosy, Siddha Vetha University, 211 Warren st, Newark, NJ 07103, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidermal growth factor receptor (EGFR) mutations drive hepatocellular carcinoma (HCC) progression, and the T790M gatekeeper substitution is the predominant mechanism of acquired resistance to EGFR-targeted therapies. Herein, we present multiscale quantum-classical

Indexed as

ErbB ReceptorsMutationPhyllanthusPhytochemicalsHumansMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingProtein Kinase InhibitorsQuantum TheoryEGFR protein, humanErbB ReceptorsPhytochemicalsProtein Kinase Inhibitorsconceptual DFTfree energy profilinggatekeeper resistancehepatocellular carcinomakinase inhibitor resistanceMM-PBSAmolecular dynamics simulationper-residue energy decomposition

Identifiers

PMID42589225
PMCPMC13465364

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.