ArticleInternational journal of molecular sciences2026
Whole Tumor Heterogeneity Topography (WTHT)-A New Approach for Assessment of Intratumor Mutational Heterogeneity in Colorectal Adenomas.
Tereza Halkova, Lucia Hodasova Pauerova, Karolina Blechova, Tereza Benesova, Tomas Grega, Nadija Brodyuk, Eva Traboulsi, Katerina Hejcmanova, Ondrej Ngo, Jan Bures and 2 more
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In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Tereza HalkovaCentre for Applied Genomics of Solid Tumors (CEGES), Genomac Research Institute, Drnovská 1112/60, 161 00 Prague, Czech Republic.ORCID 0009-0000-2985-7145 Lucia Hodasova PauerovaCentre for Applied Genomics of Solid Tumors (CEGES), Genomac Research Institute, Drnovská 1112/60, 161 00 Prague, Czech Republic.ORCID 0009-0002-1650-760X Karolina BlechovaCentre for Applied Genomics of Solid Tumors (CEGES), Genomac Research Institute, Drnovská 1112/60, 161 00 Prague, Czech Republic.
Tereza BenesovaCentre for Applied Genomics of Solid Tumors (CEGES), Genomac Research Institute, Drnovská 1112/60, 161 00 Prague, Czech Republic.
Tomas GregaDepartment of Internal Medicine, 1st Faculty of Medicine, Military University Hospital Prague, Charles University, Prague, U Vojenske Nemocnice 1200, 169 02 Prague, Czech Republic.
Nadija BrodyukDepartment of Internal Medicine, 1st Faculty of Medicine, Military University Hospital Prague, Charles University, Prague, U Vojenske Nemocnice 1200, 169 02 Prague, Czech Republic.
Eva TraboulsiDepartment of Pathology, Military University Hospital Prague, U Vojenske Nemocnice 1200, 169 02 Prague, Czech Republic.
Katerina HejcmanovaInstitute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 601 77 Brno, Czech Republic.ORCID 0000-0003-1385-7655 Ondrej NgoInstitute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 601 77 Brno, Czech Republic.
Jan BuresDepartment of Gastrointestinal Oncology, 1st Faculty of Medicine, Military University Hospital Prague, Charles University, Prague, U Vojenske Nemocnice 1200, 169 02 Prague, Czech Republic.ORCID 0000-0003-0326-117X Stepan SuchanekDepartment of Internal Medicine, 1st Faculty of Medicine, Military University Hospital Prague, Charles University, Prague, U Vojenske Nemocnice 1200, 169 02 Prague, Czech Republic.ORCID 0000-0003-3659-0252 Lucie BenesovaCentre for Applied Genomics of Solid Tumors (CEGES), Genomac Research Institute, Drnovská 1112/60, 161 00 Prague, Czech Republic.
Funding
Ministry of Health NU22-08-00424
6 · The paper itselfAbstract
Intratumor heterogeneity (ITH) of premalignant colorectal lesions is an important area of research for understanding the diverse biological behavior of colorectal cancer (CRC). Accurate assessment of ITH depends substantially on the sampling strategy used. We present a novel methodological approach termed whole tumor heterogeneity topography (WTHT) and compare it with three previously described sampling strategies: whole tumor homogenization, macrodissection of selected tumor regions, and multisampling. A cohort of 184 advanced precancerous colorectal lesions was processed into paraffin blocks, and the entire tumor mass was systematically divided into equally sized samples (~10 mm
Indexed as
AdenomaColorectal NeoplasmsGenetic HeterogeneityMutationClass I Phosphatidylinositol 3-KinasesDNA Mutational AnalysisFemaleHumansMaleMiddle AgedProto-Oncogene Proteins B-rafClass I Phosphatidylinositol 3-KinasesProto-Oncogene Proteins B-rafcolorectal adenomaindex lesionintratumor mutation heterogeneitymutation clonewhole tumor heterogeneity topography
Identifiers
PMID42589206
PMCPMC13465348
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