Evidence map›Paper›PMID 42589205›Full record

ArticleInternational journal of molecular sciences2026

ROS-Responsive Micelles Loaded with Podophyllotoxin Inhibit Tumor Growth via ROS Self-Amplification and Regulation of Survivin and p21 Expression.

Shuaiheng Song, Qiang Shao, Siyi Liang, Haoyang Du, Qingnan Zhao, Jing Guan, Ping Lin, Feng Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuaiheng SongDepartment of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Qiang ShaoDepartment of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Siyi LiangDepartment of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Haoyang DuDepartment of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Qingnan ZhaoDepartment of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Jing GuanDepartment of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Ping LinDepartment of Biochemistry and Molecular Biology, College of Basic Medical Science, Harbin Medical University, Harbin 150081, China.
Feng LinDepartment of Organic Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Podophyllotoxin (PPT) inhibits tumors such as lung cancer and breast cancer. However, it has poor water solubility and causes gastrointestinal dysfunction and bone marrow suppression, which severely limit its clinical application. Based on the differential reactive oxygen species (ROS) levels between tumor microenvironments and normal tissues, we designed and constructed a ROS-responsive micelle delivery system, successfully fabricating blank micelles (M) and PPT-loaded micelles (M@PPT). Both micelles exhibited good particle size uniformity, colloidal stability, and biosafety. The ROS responsiveness experiment revealed that, after incubating blank micelles (M) with 10 mM H

Indexed as

Cyclin-Dependent Kinase Inhibitor p21MicellesPodophyllotoxinReactive Oxygen SpeciesSurvivinAcroleinAnimalsApoptosisCell Line, TumorCell ProliferationHumansHydrogen PeroxideMiceMice, NudeParticle SizeAcroleincinnamaldehydeCyclin-Dependent Kinase Inhibitor p21Hydrogen PeroxideMicellesPodophyllotoxinReactive Oxygen SpeciesSurvivincinnamaldehydemicellespodophyllotoxinROS responsethioacetal

Identifiers

PMID42589205
PMCPMC13466196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.