Evidence map›Paper›PMID 42589043›Full record

ArticleAnimals : an open access journal from MDPI2026

Peste Des Petits Ruminants Virus Infection Induces Syncytium Formation via RhoA-Rock1 Signaling Pathway to Promote Viral Replication.

Wei Li, Hongnuan Wang, Chenyu Song, Rong Pang, Hanwei Yin, Mengyuan Liu, Xiaozhu Yang, Zilong Sun, Ding Zhang, Jingyu Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wei LiShanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China.
Hongnuan WangShanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China.
Chenyu SongShanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China.
Rong PangShanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China.
Hanwei YinShanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China.
Mengyuan LiuShanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China.
Xiaozhu YangShanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China.
Zilong SunCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China.
Ding ZhangCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong 030801, China.
Jingyu WangCollege of Veterinary Medicine, Northwest A&F University, Yangling 712100, China.
Bo WenCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology, Xinxiang 453000, China.
Bo YangShanxi Key Laboratory of Animal Disease Research, Prevention and Control, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Jinzhong 030801, China.

Funding

National Natural Science Foundation of China 32473020National Natural Science Foundation of China 32503082Outstanding Youth Foundation of He'nan Scientific Committee 262300421115Shanxi Agricultural University's Initiation Project of Introducing Talents for Scientific Research 2024XG002the special fund for Science and Technology Innovation Teams of Shanxi Province 202304051001041Young Science and Technology Leadership Program of Shanxi Agricultural University 2023YQPYGC03
6 · The paper itself

Abstract

Peste des petits ruminants (PPR) is an acute, severe, and highly contagious disease caused by peste des petits ruminants virus (PPRV), which primarily induces tissue damage through the formation of syncytia. Therefore, elucidating the molecular mechanism underlying PPRV-induced syncytium formation is of critical importance. In this study, we generated Vero CCL-81 cell lines stably expressing the PPRV receptors SLAM (lymphocytic) or Nectin-4 (epithelial) and further found that PPRV infection significantly induced syncytium formation in these cell lines as well as in goat mammary epithelial cells (GMECs) and ovine rumen epithelial cells (ORECs). Furthermore, the viral H and F proteins served as the pivotal determinants of syncytium formation. More importantly, we discovered that PPRV-induced syncytium formation is dependent on the RhoA-Rock1 signaling pathway and that inhibition of syncytium formation markedly suppressed PPRV replication. Collectively, our findings provide novel insights into the molecular mechanism of PPRV-induced syncytium formation, offer theoretical references for the development of new antiviral strategies, and advance the scientific eradication of PPR.

Indexed as

peste des petits ruminants virusRhoA-Rock1 signaling pathwaysyncytium formationviral replication

Identifiers

PMID42589043
PMCPMC13465643

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.