Evidence map›Paper›PMID 42588945›Full record

ArticleAnimals : an open access journal from MDPI2026

Plasma Homocysteine Concentrations in Horses with Left-Sided Valvular Heart Disease.

Patricia Egli, Elizabeth Williams Louie, Martina Stirn, Gunther van Loon, Annelies Decloedt, Colin C Schwarzwald, Katharyn J Mitchell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Patricia EgliEquine Department, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.ORCID 0009-0000-0409-7784
Elizabeth Williams LouieDepartment of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-7910-8740
Martina StirnClinical Laboratory, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
Gunther van LoonEquine Cardioteam Ghent, Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.ORCID 0000-0001-5191-5241
Annelies DecloedtEquine Cardioteam Ghent, Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.ORCID 0000-0001-8129-2006
Colin C SchwarzwaldEquine Department, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0002-6095-5402
Katharyn J MitchellEquine Department, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0002-5545-5630

Funding

Graduate Training Program in Comparative MedicineT32OD011000 · OD · CORNELL UNIVERSITY · PI Amanda Marjorie DE MESTRE · 2012 to 2026
$5.7M
NIH HHS T32 OD011000Stiftung Pro Pferd, University of Zurich
6 · The paper itself

Abstract

In human medicine, homocysteine, a sulfur-containing amino acid, is used as a biomarker reflecting endothelial dysfunction, inflammation, thrombogenesis, oxidative stress and cardiovascular disease. An automated enzyme-cycling assay for homocysteine, established for humans, has been validated and reference ranges have been created for horses. In this study the homocysteine assay was further evaluated by assessing short-term stability (whole blood and plasma samples stored at 4 °C and room temperature for 24 h), long-term stability (two years), the effect of different anticoagulants (lithium heparin, sodium citrate, EDTA, no additives) and repeated freeze-thaw cycles (five times). Further, associations between plasma homocysteine concentrations ([HCY]

Indexed as

cardiac biomarkerequinehearthyperhomocysteinemiaregurgitation

Identifiers

PMID42588945
PMCPMC13463591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.