Evidence map›Paper›PMID 42588741›Full record

ReviewCancers2026

The Genetic Landscape of Colorectal Cancer: From Molecular Alterations to Therapeutic Decision Pathways.

Cristina Maria Macrea, Tiberia Ilias, Alexandra Costea, Paula Trif, Viorela-Romina Murvai, Ovidiu C Fratila

Abstract readReview
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cristina Maria MacreaDoctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.
Tiberia IliasDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.
Alexandra CosteaDoctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.
Paula TrifDoctoral School of Biological and Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.
Viorela-Romina MurvaiDepartment of Obstetrics and Gynecology, Calla-Infertility Diagnostic and Treatment Center, Constantin A. Rosetti Street, 410103 Oradea, Romania.
Ovidiu C FratilaDepartment of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.

Funding

University of Oradea University research
6 · The paper itself

Abstract

Colorectal cancer (CRC) remains one of the leading causes of cancer-related morbidity and mortality worldwide despite substantial advances in screening, surgical techniques, systemic therapies, and multidisciplinary care. The increasing implementation of precision oncology has fundamentally transformed CRC management by enabling molecularly guided therapeutic strategies based on tumor-specific genetic alterations. In recent years, the molecular landscape of CRC has expanded considerably beyond traditional histopathological classification, incorporating a growing number of clinically actionable biomarkers with prognostic, predictive, and therapeutic significance. This review provides a comprehensive and up-to-date overview of the genetic landscape of CRC, focusing on established biomarkers currently integrated into clinical practice, including microsatellite instability/mismatch repair deficiency (MSI/dMMR),

Indexed as

artificial intelligenceBRAFcolorectal cancerctDNAHER2KRASmolecular biomarkersMSINTRKpersonalized medicineprecision oncologytranscriptomicstumor mutational burden

Identifiers

PMID42588741
PMCPMC13464850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.