Evidence map›Paper›PMID 42588655›Full record

ArticleCancers2026

Oxidative DNA Damage Is Associated with Immune Remodeling and Therapeutic Response in High-Grade Serous Ovarian Cancer.

Carson C Edwards, Jenna M Hedlich-Dwyer, Jianqing Zhang, Valeria L Dal Zotto, Dongquan Chen, Rebecca C Arend, Natalie R Gassman

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carson C EdwardsDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0009-0009-1493-5601
Jenna M Hedlich-DwyerDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Jianqing ZhangDepartment of Radiation Oncology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-5246-3371
Valeria L Dal ZottoDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Dongquan ChenDepartment of Medicine, Division of General Internal Medicine & Population Science, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Rebecca C ArendDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Natalie R GassmanDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0002-8488-2332

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN · 2009 to 2026
$37.0M
CTSA UM1 at the University of Alabama at BirminghamUM1TR004771 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PATRICE DELAFONTAINE, Orlando M Gutierrez · 2024 to 2026
$29.2M
Department of Defense Ovarian Cancer Research Program W81XWH1910410Mayo Cancer Center P30 CA015083Mayo Clinic SPORE in Ovarian Cancer National Institutes of Health P50 CA136393National Center for Advancing Translational Sciences of the National Institutes of Health UM1TR004771 and UL1TR003096NCATS NIH HHS UL1 TR003096NCATS NIH HHS UM1 TR004771NCI NIH HHS P30 CA013148NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA136393UAB O'Neal Comprehensive Cancer Center P30 CA013148
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

adaptive immunityDNA damageneoadjuvant chemotherapyovarian canceroxidative stresstumor–immune microenvironment

Identifiers

PMID42588655
PMCPMC13465026

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.