Evidence map›Paper›PMID 42588596›Full record

ArticleCancers2026

PAX3::FOXO1-Targeting PROTAC Induces Myogenic Differentiation of Fusion-Positive Rhabdomyosarcoma Cells.

Nikola Knoll, Kayra Somay, Purushottam B Tiwari, Emre Deniz, Jeffrey S S K Formen, Isabel Frye, Eryn Nelson, Christian Wolf, Jeffrey A Toretsky, Aykut Üren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nikola KnollLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.
Kayra SomayLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.ORCID 0000-0001-5089-4653
Purushottam B TiwariLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.ORCID 0000-0002-3140-0723
Emre DenizLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.ORCID 0000-0002-9635-983X
Jeffrey S S K FormenChemistry Department, Georgetown University, Washington, DC 20057, USA.
Isabel FryeLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.
Eryn NelsonChemistry Department, Georgetown University, Washington, DC 20057, USA.
Christian WolfChemistry Department, Georgetown University, Washington, DC 20057, USA.ORCID 0000-0002-4447-3753
Jeffrey A ToretskyLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.ORCID 0000-0003-3619-2879
Aykut ÜrenLombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.ORCID 0000-0002-2033-1216

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
Screening small molecules for rhabdomyosarcoma fusion proteinsR21CA220087 · NCI · GEORGETOWN UNIVERSITY · PI UREN, AYKUT · 2020 to 2021
$400k
Alex's Lemonade Stand Foundation 1269066, 22-27123, 21-24878, 1449882Jeff Gordon Children's FoundationNCI NIH HHS 1 R21 CA220087-01A1NCI NIH HHS P30 CA 051008NCI NIH HHS P30 CA051008NCI NIH HHS R21 CA220087The Children's Cancer Foundation
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

fusion-positive rhabdomyosarcomaoncogenic fusion proteinPAX3::FOXO1pediatric sarcomaPROTAC

Identifiers

PMID42588596
PMCPMC13465285

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.