ArticleMolecules (Basel, Switzerland)2026
Cholesterol and Albumin as Key Modulators of ICG Photostability in Aqueous Solution.
Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Indocyanine green (ICG) is a clinically approved near-infrared fluorescent dye used in medical imaging and diagnostics but has limitations owing to its poor photostability in aqueous environments. This paper has explored the role of human serum albumin (HSA) and cholesterol in protecting ICG photostability. Pure ICG, an HSA-ICG complex, and an ICG-cholesterol colloidal assembly solution were stirred in the dark (control) and under continuous broadband irradiation (400-1600 nm, approximately 1.4 W), and absorption spectra (550-950 nm) were taken every 1 min, over 15 min. All the formulations were stable in the dark, with minimal total variance in absorbance. Pure ICG significantly photodegraded under irradiation (55 ± 2.75-65 ± 3.25% loss of maximum absorbance). The introduction of HSA and cholesterol limited the photodegradation, resulting in 15 ± 0.75-30 ± 1.5% and 25 ± 1.25% losses in maximum absorbance, respectively, upon irradiation. The modulators produced a significant increment in initial NIR absorbance (
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