ArticleMolecules (Basel, Switzerland)2026
Further Investigations on Natural and Synthetic Bis-(1,2,3,4-tetrahydroisoquinoline) Derivatives Interacting with the Apamin-Sensitive Site of Small-Conductance Calcium-Activated Potassium Channels.
Hossein Taouba, Romain Vitello, Donna Pereira Barbon, Jean-Luc Hayen, Coralie Herbet, Szymon Piotr Faliński, Nikolay Tumanov, Johan Wouters, Jean-François Liégeois
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Hossein TaoubaLaboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, 4000 Liège, Belgium.ORCID 0009-0004-6286-9091 Romain VitelloLaboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, 4000 Liège, Belgium.ORCID 0000-0002-4027-5207 Donna Pereira BarbonLaboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, 4000 Liège, Belgium.
Jean-Luc HayenLaboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, 4000 Liège, Belgium.ORCID 0009-0000-3370-9153 Coralie HerbetLaboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, 4000 Liège, Belgium.ORCID 0009-0003-9304-1118 Szymon Piotr FalińskiLaboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, 4000 Liège, Belgium.
Nikolay TumanovNamur Institute of Structured Matter (NISM) and Namur Research Institute for Life Sciences (NARILIS) Research Institutes, Department of Chemistry, University of Namur, 5000 Namur, Belgium.ORCID 0000-0001-6898-9036 Johan WoutersNamur Institute of Structured Matter (NISM) and Namur Research Institute for Life Sciences (NARILIS) Research Institutes, Department of Chemistry, University of Namur, 5000 Namur, Belgium.ORCID 0000-0002-4920-6857 Jean-François LiégeoisLaboratory of Medicinal Chemistry, Center for Interdisciplinary Research on Medicines (CIRM), University of Liège, 4000 Liège, Belgium.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Our previous study demonstrated that bis-(1,2,3,4-tetrahydroisoquinoline) (bis-THIQ) compounds such as tetrandrine and AG525E1 exhibit significant affinity for SK channels. Interestingly, the stereoisomers of AG525 display markedly different affinities toward SK channels, with the (
Indexed as
ApaminSmall-Conductance Calcium-Activated Potassium ChannelsTetrahydroisoquinolinesBenzylisoquinolinesBinding SitesLigandsModels, MolecularPharmacophoreProtein BindingStructure-Activity Relationship1,2,3,4-tetrahydroisoquinolineApaminBenzylisoquinolinesLigandsSmall-Conductance Calcium-Activated Potassium ChannelsTetrahydroisoquinolines1,2,3,4-tetrahydroisoquinolineaffinityalkaloidsbindingin silicoKCa2.2KCa2.3pharmacophoreSK channels
Identifiers
PMID42588569
PMCPMC13468207
What OpenQuestion holds
Textmetadata
Read underepoch 390