Evidence map›Paper›PMID 42588534›Full record

ArticleMolecules (Basel, Switzerland)2026

Investigations of the Molecular Nature of Low-Molecular-Mass Copper(II) Ion Complexes in Human Saliva: Physiological and Toxicological Significance.

Kayleigh Hunwin, Oliver Megram, Georgina Page, Wyman Chan, Nazmin Juma, Rachel Armitage, Olivia Steel, Katie Jane Hewitt, Martin Grootveld

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kayleigh HunwinLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Oliver MegramLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.ORCID 0000-0001-9815-0389
Georgina PageLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Wyman ChanLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Nazmin JumaLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Rachel ArmitageSchool of Heritage and Culture, University of Leicester, University Road, Leicester LE1 7RH, UK.
Olivia SteelLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Katie Jane HewittLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.ORCID 0009-0005-0792-5326
Martin GrootveldLeicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.ORCID 0000-0003-1502-3734

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Copper is an essential trace element that plays critical roles in enzymatic processes and cellular metabolism. However, excessive exposure to its ions can lead to toxicity through oxidative stress mechanisms. Therefore, the chemical 'speciation' of copper(II) ions (Cu(II)) in biological fluids such as saliva is of critical importance. However, currently this phenomenon remains poorly understood, despite its importance for our understanding of bioavailability, toxicity, and sensory perception. Therefore, this study employed

Indexed as

Coordination ComplexesCopperSalivaAdultHumansIonsMolecular WeightSpectroscopy, Fourier Transform InfraredCoordination ComplexesCopperIons1H NMR spectroscopybioavailabilitycopper(II) ion speciationdietary copperFTIR-ATRhuman salivametal ion–biomolecule interactionsmetallic tastetoxicology

Identifiers

PMID42588534
PMCPMC13468485

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.