Cyclic Monoterpene-Aromatic Hybrids from Chiral Pool Terpenoid Ketones: Practical Synthetic Methodology for Accessing Them and In Silico Assessment as Cannabinoid Receptor CB1/CB2 Ligands.

Vasiliki Kaikiti, Andrea Jaksic, Basharat Ali, Savvas N Georgiades

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vasiliki KaikitiDepartment of Chemistry, University of Cyprus, 1 Panepistimiou Avenue, Nicosia 2109, Cyprus.ORCID 0009-0003-6690-0562

Andrea JaksicDepartment of Chemistry, University of Cyprus, 1 Panepistimiou Avenue, Nicosia 2109, Cyprus.

Basharat AliInstitute of Chemistry, Khawaja Fareed University of Engineering and Information Technology, Rahim Yar Khan 64200, Pakistan.ORCID 0000-0002-8952-2432

Savvas N GeorgiadesDepartment of Chemistry, University of Cyprus, 1 Panepistimiou Avenue, Nicosia 2109, Cyprus.ORCID 0000-0002-6106-9904

Funding

University of Cyprus internal allocation (no grant number)

6 · The paper itself

Abstract

Natural products featuring a direct σ-bond between a cyclic monoterpene and an aromatic moiety provide a vast source of biological activities, such as antimicrobial, anticancer, antiviral, anticoagulant and cannabinoid regulatory, among others. Only few methods exist for synthetically accessing such hybrid structures and their analogs, all of which are prone to limitations, most notably the reliance on sensitive organometallic intermediates and the difficulty in furnishing certain stereoisomers. An efficient, three-stage synthetic methodology is described herein, that enables the production of hybrid structures featuring a C(sp

Indexed as

KetonesMonoterpenesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2TerpenesLigandsMolecular Docking SimulationMolecular StructureStereoisomerismKetonesLigandsMonoterpenesReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Terpenesaromatic terpenoidscannabinoid mimicscyclic monoterpenesenol triflatestereoselective hydrogenationSuzuki–Miyaura C-C cross-coupling

Identifiers

PMID42588449

DOI10.3390/molecules31152599

PMCPMC13467945

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.