Evidence map›Paper›PMID 42588197›Full record

ReviewNutrients2026

The Case for Vinegar Ingestion.

Carol S Johnston

Abstract readReview
In one paragraph

Review in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Carol S JohnstonNutrition Program, College of Health Solutions, Arizona State University, Phoenix, AZ 85004, USA.ORCID 0000-0001-9540-6860

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acetate is emerging as an influencer of wellbeing. The interest in acetate parallels the mounting reports of preclinical and small-scale clinical investigations over the past two decades suggesting the health benefits of vinegar, a dietary source of acetic acid along with fermented and pickled foods. Additionally, acetic acid is generated during fermentation by the gut microbiome and is considered a main benefit of the gut microbiome. However, numerous factors adversely impact acetic acid production by gut microbiota such as medications, disease states, and low fiber intakes. Since acetic acid rapidly deprotonates when entering the blood stream, it is a source of systemic acetate. A third source of acetate is endogenous production by various tissues via deacetylation reactions, and endogenous acetate production is 2-fold that generated by microbiota fermentation. This narrative review highlights acetate metabolism and impacts on health parameters as well as the role of vinegar in health promotion as an exogenous source of acetic acid.

Indexed as

Acetic AcidAcetatesAnimalsFermentationHumansAcetatesAcetic Acidacetateacetic acidacetyl-CoAAMPKdeacetylationvinegar

Identifiers

PMID42588197
PMCPMC13467789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.