Evidence map›Paper›PMID 42588192›Full record

ArticleNutrients2026

Mechanistic Insights into Milk Minerals Driving Bone Development and Mineralization in Growing Rats.

Yile Peng, Yalin Zhou, Simon Bøge Riis, Jing Yin, Muke Han, Zhang Wen, Wanyun Ye, Xudong Liu, Weiwei Shi, Xuezeng Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yile PengDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100083, China.
Yalin ZhouDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100083, China.ORCID 0000-0002-9085-1487
Simon Bøge RiisArla Food Ingredients Group P/S, Sønderhøj 10-12, 8260 Viby J, Denmark.
Jing YinArla Food Ingredients Group P/S, Sønderhøj 10-12, 8260 Viby J, Denmark.
Muke HanDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100083, China.
Zhang WenDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100083, China.
Wanyun YeDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100083, China.
Xudong LiuDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100083, China.
Weiwei ShiDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100083, China.
Xuezeng WangDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100083, China.
Jiahui LuoDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100083, China.
Yajun XuDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, No. 38 Xueyuan Road, Beijing 100083, China.ORCID 0000-0001-5791-4629

Funding

National Key Research and Development Program of China No.2023YFE0114200
6 · The paper itself

Abstract

objectiveTo investigate the effect of milk minerals on bone mineral density (BMD) and bone quality in growing rats and explore the underlying mechanisms related to calcium absorption, bone metabolism, and the gut-bone axis.

methodsSixty healthy 4-week-old male Sprague-Dawley (SD) rats were randomly divided to five groups based on their body weight: Low-Calcium Control Group (Control), Low-Dose milk mineral Group (Low), Medium-Dose milk mineral Group (Medium), High-Dose milk mineral Group (High) and Calcium Carbonate Control Group (CaCO

resultMilk mineral exhibited non-inferior efficacy to CaCO

conclusionsMilk mineral supplementation appears to promote bone formation and mineralization in growing rats, accompanied by enhanced intestinal calcium absorption, enrichment of characteristic gut microbes and elevated microbial metabolite concentrations.

Indexed as

Bone DevelopmentCalcification, PhysiologicMilkMineralsAnimalsBone DensityCalciumCalcium CarbonateCalcium, DietaryFemurGastrointestinal MicrobiomeMaleRatsRats, Sprague-DawleyCalciumCalcium CarbonateCalcium, DietaryMineralsbone mineral densitygut microbiotamilk mineralsmineralization

Identifiers

PMID42588192
PMCPMC13468487

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.