Lactic Acid Bacteria-Derived γ-Aminobutyric Acid: From Targeted Screening and Biosynthesis to Functional Food Applications and Health Benefits.

Yuqian Zhang, Xue Zhou, Dan Zheng, Xuezhi Yuan, Shuyun Xu, Jiangyu Zhu, Weiwei Cheng

Abstract readReview

In one paragraph

Review in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuqian ZhangSchool of Chemistry and Bioengineering, Nanjing Normal University Taizhou College, Taizhou 225300, China.

Xue ZhouSchool of Chemistry and Bioengineering, Nanjing Normal University Taizhou College, Taizhou 225300, China.

Dan ZhengSchool of Chemistry and Bioengineering, Nanjing Normal University Taizhou College, Taizhou 225300, China.

Xuezhi YuanSchool of Chemistry and Bioengineering, Nanjing Normal University Taizhou College, Taizhou 225300, China.

Shuyun XuSchool of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China.

Jiangyu ZhuSchool of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China.ORCID 0000-0003-3673-6004

Weiwei ChengSchool of Chemistry and Bioengineering, Nanjing Normal University Taizhou College, Taizhou 225300, China.

Funding

China Postdoctoral Science Foundation No. 2024M762732National Natural Science Foundation of China No. 22208285

6 · The paper itself

Abstract

γ-Aminobutyric acid (GABA) is a non-proteinogenic amino acid that acts as a major signaling molecule across the nervous, cardiovascular, and immune systems. While GABA has historically been produced via chemical synthesis or plant extraction, microbial fermentation using lactic acid bacteria (LAB) provides a safe, sustainable, and food-grade alternative. This review details the recent progress of LAB-derived GABA, covering the workflow from strain selection to functional food applications. We discuss how modern screening methods combine high-throughput phenotypic testing with genomic mining of the

Indexed as

functional foodsglutamate decarboxylasehigh-throughput screeninglactic acid bacteriametabolic engineeringγ-aminobutyric acid

Identifiers

PMID42587902

DOI10.3390/foods15152642

PMCPMC13464983

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.