Evidence map›Paper›PMID 42587826›Full record

ArticleCells2026

Expression Defects of SCN5A Common Polymorphisms S524Y and H558R in the Q1077 Splice Variant Can Be Rescued by Mexiletine.

Rou-Mu Hu, Evelyn J Song, Carmen R Valdivia, Isabelle Deschenes, Jonathan C Makielski, Bi-Hua Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rou-Mu HuHeart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Evelyn J SongDivision of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, CA 94403, USA.ORCID 0000-0003-2616-0814
Carmen R ValdiviaDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison, WI 53726, USA.ORCID 0000-0003-1224-3088
Isabelle DeschenesDepartment of Physiology and Cell Biology, The Dorothy M. Davis Heart and Lung Research Institute, Frick Center for Heart Failure and Arrhythmia, The Ohio State University, Columbus, OH 43210, USA.
Jonathan C MakielskiDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison, WI 53726, USA.
Bi-Hua TanDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin, Madison, WI 53726, USA.

Funding

American Heart Association 0525806ZAmerican Heart Association 11SDG7470009Beijing Hospitals Authority Youth Programme QML2019305National Natural Science Foundation 81800293
6 · The paper itself

Abstract

The cardiac sodium channel Na

Indexed as

Alternative SplicingMexiletineNAV1.5 Voltage-Gated Sodium ChannelPolymorphism, GeneticRNA SplicingHEK293 CellsHumansMutationMexiletineNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humancommon polymorphismmexiletineSCN5Asplice variant

Identifiers

PMID42587826
PMCPMC13465417

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.