GLUD1 Inhibition Disrupts Glutamate Homeostasis and Induces Metabolic and Redox Stress in Gliomas.

Malgorzata Trybula, Małgorzata Łysiak, Emilia Wiechec, Annika Malmström, Peter Söderkvist

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Malgorzata TrybulaDepartment of Biomedical and Clinical Sciences, Division of Cell and Neurobiology, Linköping University, 581 83 Linköping, Sweden.

Małgorzata ŁysiakClinical Genomics Linköping and Department of Biomedical and Clinical Sciences, Linköping University, 581 83 Linköping, Sweden.ORCID 0000-0002-0244-759X

Emilia WiechecDepartment of Biomedical and Clinical Sciences, Division of Cell and Neurobiology, Linköping University, 581 83 Linköping, Sweden.ORCID 0000-0003-0270-9374

Annika MalmströmDepartment of Biomedical and Clinical Sciences, Division of Cell and Neurobiology, Linköping University, 581 83 Linköping, Sweden.ORCID 0000-0001-8410-4939

Peter SöderkvistDepartment of Biomedical and Clinical Sciences, Division of Cell and Neurobiology, Linköping University, 581 83 Linköping, Sweden.ORCID 0000-0001-9867-8706

Funding

Swedish Cancer Society 24 3598PJ

6 · The paper itself

Abstract

Glutamate dehydrogenase (GLUD1) links glutamine metabolism and redox regulation, yet its prognostic and functional relevance across different glioma subtypes warrants further study. Here, we show that

Indexed as

Brain NeoplasmsGliomaGlutamate DehydrogenaseGlutamic AcidHomeostasisOxidative StressCell Line, TumorCell SurvivalHumansIsocitrate DehydrogenaseMembrane Potential, MitochondrialOxidation-ReductionReactive Oxygen SpeciesGLUD1 protein, humanGlutamate DehydrogenaseGlutamic AcidIsocitrate DehydrogenaseReactive Oxygen Speciescancer metabolismgliomaGLUD1glutamate dysregulationredox

Identifiers

PMID42587809

DOI10.3390/cells15151401

PMCPMC13465080

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.