Evidence map›Paper›PMID 42587796›Full record

ArticleCells2026

Loss of Copine D Leads to Ras Activation in

Cody T Morrison, Sela K Damer-Daigle, Allison G Maillette, Cynthia K Damer

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Cody T MorrisonBiochemistry, Cell & Molecular Biology Program, Central Michigan University, Mount Pleasant, MI 48859, USA.ORCID 0000-0002-9148-2310
Sela K Damer-DaigleDepartment of Biology, Central Michigan University, Mount Pleasant, MI 48859, USA.
Allison G MailletteDepartment of Biology, Central Michigan University, Mount Pleasant, MI 48859, USA.
Cynthia K DamerBiochemistry, Cell & Molecular Biology Program, Central Michigan University, Mount Pleasant, MI 48859, USA.ORCID 0000-0003-2059-5294

Funding

The role of copines in the regulation of the actin cytoskeleton and membrane traffickingR15GM078089 · NIGMS · CENTRAL MICHIGAN UNIVERSITY · PI CYNTHIA K DAMER · 2008 to 2026
$1.6M
NIGMS NIH HHS R15 GM078089NIH HHS 2R15GM078089-03
6 · The paper itself

Abstract

Copines are a family of calcium-dependent phospholipid-binding proteins conserved across numerous eukaryotes. The expression of multiple copine genes is dysregulated in several human cancers, yet their molecular functions remain poorly understood. We are investigating copine genes (

Indexed as

DictyosteliumProtozoan Proteinsras ProteinsCarrier ProteinsCell ProliferationChemotaxisCyclic AMPMutationPhosphatidylinositol 3-KinasesSignal TransductionCarrier ProteinscopineCyclic AMPPhosphatidylinositol 3-KinasesProtozoan Proteinsras Proteinscellular signalingchemotaxisCopine DcopinesDictyostelium discoideumPI3KRasREMIrestriction enzyme-mediated integration

Identifiers

PMID42587796
PMCPMC13465345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.