Evidence map›Paper›PMID 42587749›Full record

ArticleCells2026

The Biological Response of Human NP Cells to Soluble Collagen VI.

Jonathan Dalton, Srikanth N Divi, Yasmine K Eichbaum, Panya Luksanapruksa, Mitchell K Ng, Rachel Huang, Alan S Hilibrand, Alexander R Vaccaro, Dessislava Z Markova, Christopher K Kepler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan DaltonDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Srikanth N DiviDepartment of Orthopedic Surgery, Northwestern Hospital, Chicago, IL 60611, USA.
Yasmine K EichbaumDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Panya LuksanapruksaDepartment of Orthopedic Surgery, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.ORCID 0000-0002-9554-4259
Mitchell K NgDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-5831-055X
Rachel HuangDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-7683-8702
Alan S HilibrandDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0001-8811-9687
Alexander R VaccaroDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0002-8073-0796
Dessislava Z MarkovaDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.ORCID 0000-0003-4387-5109
Christopher K KeplerDepartment of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular matrix (ECM) dysregulation plays a significant role in the development of intervertebral disc disease (IVDD). The ECM around the chondrocytes in the nucleus pulposus (NP) is unique in that it contains ColVI. While linked to chondrocyte proliferation in cartilage, ColVI's specific role in IVD degeneration is less clear. Our aim was to determine the expression of ColVI in NP cells from degenerative IVDs, along with the effects of soluble ColVI on NP cells. Thus, we compared the expression levels of ColVI in human degenerated IVD samples, along with the effect of soluble ColVI on primary human NP cells. A higher Pfirrmann grade was associated with increased

Indexed as

Collagen Type VINucleus PulposusAdultCell ProliferationCells, CulturedExtracellular MatrixFemaleHumansInsulin-Like Growth Factor IIntervertebral Disc DegenerationMaleMiddle AgedRNA, MessengerSolubilityCol6a1 protein, humanCollagen Type VIInsulin-Like Growth Factor IRNA, Messengercollagen type VIdegenerative disc diseaseintervertebral disc degenerationnucleus pulposus

Identifiers

PMID42587749
PMCPMC13465566

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.