ReviewCells2026
From Load-Bearing Tissue to Failed Filter: A Conceptual Framework for Trabecular Meshwork Breakdown in Pseudoexfoliation Glaucoma.
Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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1 author.
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Abstract
Pseudoexfoliation glaucoma (PXG) is a unique cause of open-angle glaucoma with a more severe clinical course and higher intraocular pressure (IOP) than primary open-angle glaucoma (POAG). This reflects progressive structural failure of the trabecular meshwork (TM) driven by pseudoexfoliation (PXF) fibrillar material deposition, distinguishing PXG from POAG pathogenically. The TM, an active load-bearing filtration sieve, regulates IOP and is most affected by XFM deposition and extracellular matrix (ECM) dysregulation in PXG. Despite extensive research, the mechanism of trabecular dysfunction remains unclear, with both mechanical obstruction and ischemic/oxidative stress implicated. This narrative review amalgamates evidence across TM biology, PXF material science, and glaucoma pathophysiology to propose a five-stage framework for TM failure in PXG.
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