Evidence map›Paper›PMID 42587734›Full record

ArticleCells2026

Transcriptional Responses to Bumped Kinase Inhibitor BKI-1708 in

Maria Cristina Ferreira de Sousa, Arunasalam Naguleswaran, Kayode K Ojo, Wesley C Van Voorhis, Andrew Hemphill

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Cristina Ferreira de SousaInstitute of Parasitology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.ORCID 0009-0007-2056-2157
Arunasalam NaguleswaranInstitute of Animal Pathology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-9509-485X
Kayode K OjoDepartment of Medicine, University of Washington, Seattle, WA 98109-4766, USA.ORCID 0000-0002-2007-2170
Wesley C Van VoorhisDepartment of Medicine, University of Washington, Seattle, WA 98109-4766, USA.
Andrew HemphillInstitute of Parasitology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-0622-2128

Funding

Bumped-Kinase Inhibitor Drug Development for ToxoplasmosisR01HD102487 · NICHD · UNIVERSITY OF WASHINGTON · PI VAN VOORHIS, WESLEY C · 2021 to 2025
$3.3M
Clinical Research Training in Infectious DiseasesT32AI055412 · NIAID · TUFTS MEDICAL CENTER · PI SNYDMAN, DAVID RICHARD · 2005 to 2014
$1.3M
NIAID NIH HHS T32 AI055412NICHD NIH HHS R01 HD102487Swiss National Science Foundation 214897
6 · The paper itself

Abstract

Bumped kinase inhibitors are safe with promising efficacy against apicomplexan parasites. The 5-aminopyrazole-4-carboxamide BKI-1708 effectively inhibited vertical transmission of

Indexed as

FibroblastsProtein Kinase InhibitorsPyrazolesToxoplasmaTranscription, GeneticAnimalsHumansMiceToxoplasmosisProtein Kinase InhibitorsPyrazolesanti-parasitic activitybumped kinase inhibitordifferential gene expressionhuman fibroblastmode of actionToxoplasmatranscriptome

Identifiers

PMID42587734
PMCPMC13465175

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.