Evidence map›Paper›PMID 42587728›Full record

ReviewCells2026

From PLP1 Misfolding to Oligodendrocyte Degeneration: A Proteostasis-Centered Framework for Pelizaeus-Merzbacher Disease.

Tianyi Li, Hao Huang, Xiaobin Li, Runlin Leng, Binbin Liu, Guohua Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tianyi LiDepartment of Medical Genetics, School of Basic Medical Science, Wuhan University, Wuhan 430071, China.
Hao HuangHubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China.
Xiaobin LiDepartment of Medical Genetics, School of Basic Medical Science, Wuhan University, Wuhan 430071, China.ORCID 0009-0007-5598-224X
Runlin LengDepartment of Medical Genetics, School of Basic Medical Science, Wuhan University, Wuhan 430071, China.
Binbin LiuDepartment of Medical Genetics, School of Basic Medical Science, Wuhan University, Wuhan 430071, China.
Guohua YangDepartment of Medical Genetics, School of Basic Medical Science, Wuhan University, Wuhan 430071, China.ORCID 0000-0001-5631-8139

Funding

Fundamental Research Funds for the Central Universities 2042025YXB003
6 · The paper itself

Abstract

Oligodendrocytes (OLs) are the myelinating cells of the central nervous system (CNS). The

Indexed as

Myelin Proteolipid ProteinOligodendrogliaPelizaeus-Merzbacher DiseaseProtein FoldingProteostasisAnimalsHumansUnfolded Protein ResponseMyelin Proteolipid ProteinPLP1 protein, humanERO1αoligodendrocytePelizaeus–Merzbacher diseasePLP1proteostasisunfolded protein response

Identifiers

PMID42587728
PMCPMC13465330

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.