Evidence map›Paper›PMID 42587687›Full record

ArticleDiagnostics (Basel, Switzerland)2026

Ruling In and Ruling Out Sepsis Using Likelihood Ratios of a Host Response Assay.

Krupa Arun Navalkar, Prashant Wani, Roy F Davis, Silvia Cermelli, Maximilian Dietrich, Maik von der Forst, Sören L Becker, Sophia Benthien, Elisa Baumann, Carsten Zeiner and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Krupa Arun NavalkarImmunexpress Inc., Seattle, WA 98109, USA.ORCID 0000-0002-4751-6130
Prashant WaniImmunexpress Inc., Seattle, WA 98109, USA.
Roy F DavisImmunexpress Inc., Seattle, WA 98109, USA.
Silvia CermelliImmunexpress Inc., Seattle, WA 98109, USA.
Maximilian DietrichDepartment of Anesthesiology, Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 420, 69120 Heidelberg, Germany.ORCID 0000-0003-0960-038X
Maik von der ForstDepartment of Anesthesiology, Medical Faculty Heidelberg, Heidelberg University, Im Neuenheimer Feld 420, 69120 Heidelberg, Germany.ORCID 0000-0002-5381-6535
Sören L BeckerInstitute of Medical Microbiology and Hygiene, Saarland University, 66421 Homburg, Germany.ORCID 0000-0003-3634-8802
Sophia BenthienInstitute of Medical Microbiology and Hygiene, Saarland University, 66421 Homburg, Germany.
Elisa BaumannInstitute of Medical Microbiology and Hygiene, Saarland University, 66421 Homburg, Germany.
Carsten ZeinerDepartment of Internal Medicine V, Pneumology and Intensive Care Medicine, Saarland University, 66421 Homburg, Germany.ORCID 0009-0006-9464-1010
Philipp M LepperDepartment of Internal Medicine, Pneumology and Intensive Care Medicine, University Hospital OWL Campus Bethel, University of Bielefeld, 33617 Bielefeld, Germany.
José Garnacho-MonteroIntensive Care Unit, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain.ORCID 0000-0003-2542-7601
María Luisa Cantón-BulnesIntensive Care Unit, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain.ORCID 0000-0003-1024-2954
Adela Fernández-GalileaIntensive Care Unit, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain.
Jose Luis García-GarmendiaIntensive Care Unit, Hospital San Juan de Dios del Aljarafe, 41930 Sevilla, Spain.ORCID 0000-0003-1443-9236
Ángel EstellaIntensive Care Unit, Hospital Universitario de Jerez de la Frontera, 11407 Cádiz, Spain.ORCID 0000-0003-0665-557X
Russell R MillerDepartment of Critical Care Medicine, FirstHealth of the Carolinas, Pinehurst, NC 28374, USA.
Marcus J SchultzDepartment of Anaesthesia, General Intensive Care and Pain Management, Division of Cardiothoracic and Vascular Anaesthesia & Critical Care Medicine, Medical University Wien, 1090 Vienna, Austria.ORCID 0000-0003-3969-7792
Richard RothmanDepartment of Emergency Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
John BurkeInfectious Diseases, Intermountain Medical Center, Murray, UT 84107, USA.
Gourang PatelDepartment of Pharmacy Services, University of Chicago Medicine, Chicago, IL 60637, USA.
Jorge ParadaInfectious Disease, Loyola University Medical Center, Maywood, IL 60153, USA.
Thomas D YagerImmunexpress Inc., Seattle, WA 98109, USA.ORCID 0000-0002-2341-2353
Richard B BrandonImmunexpress Inc., Seattle, WA 98109, USA.

Funding

Biomedical Advanced Research and Development Authority 75A50120C00125Immunexpress, Inc.
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

blood culturediagnostic accuracygene expressionhost-response biomarkerintensive care unitlikelihood ratiosepsisSeptiCyte RAPIDSeptiScoresystemic inflammatory response syndrome

Identifiers

PMID42587687
PMCPMC13465465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.