Evidence map›Paper›PMID 42587342›Full record

ArticleChemMedChem2026

Synthesis of 1,3,5-Triazine-Indole Conjugates as Broad-Spectrum Coronavirus Entry Inhibitors.

Shazia Asghar, Leentje Persoons, Yanicka Smolders, Niels Willems, Dirk Daelemans, Steven De Jonghe, Najim A Al-Masoudi, Shahid Hameed

Abstract read
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shazia AsgharDepartment of Chemistry, Quaid-I-Azam University, Islamabad, Pakistan.
Leentje PersoonsDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-7898-0868
Yanicka SmoldersDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, KU Leuven, Leuven, Belgium.
Niels WillemsDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, KU Leuven, Leuven, Belgium.
Dirk DaelemansDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0001-7092-1153
Steven De JongheDepartment of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Molecular Genetics and Therapeutics in Virology and Oncology Research Group, KU Leuven, Leuven, Belgium.ORCID https://orcid.org/0000-0002-3872-6558
Najim A Al-MasoudiDepartment of Chemistry, College of Science, University of Basrah, Basrah, Iraq.ORCID https://orcid.org/0000-0001-6811-191X
Shahid HameedDepartment of Chemistry, Quaid-I-Azam University, Islamabad, Pakistan.ORCID https://orcid.org/0000-0002-1195-1659

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of hybrid molecules containing indole and 1,3,5-triazine scaffolds was synthesized and evaluated for their antiviral activity against several human RNA and DNA viruses. The conjugates displayed overall low cytotoxicity (CC

Indexed as

Antiviral AgentsIndolesSARS-CoV-2TriazinesVirus InternalizationAnimalsHumansMicrobial Sensitivity TestsStructure-Activity RelationshipAntiviral AgentsIndolesTriazines1,3,5‐triazinescoronavirus entry inhibitorsindole‐2‐carbohydrazidesSARS‐CoV‐2

Identifiers

PMID42587342
PMCPMC13469574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.