ArticleAdvanced healthcare materials2026
A Self-Adaptive Programming Strategy Enables Local Microenvironment Modulation and Temporal Immunomodulation for Diabetic Infected Bone Regeneration.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The repair of diabetic bone defects remains challenging due to disrupted bone immune homeostasis and increased susceptibility to infection. Under hyperglycemic conditions, the immune microenvironment fails to switch between the pro-inflammatory environment required for pathogen clearance and the anti-inflammatory environment for osteogenesis. Here, a glucose-responsive hydrogel (PEG-ZnO-sita) is developed by integrating zinc oxide (ZnO) and sitagliptin into a network formed by dopamine-modified tetra-armed poly(ethylene glycol) succinimidyl glutarate (DA-PEG-SG) and phenylboronic acid-modified gelatin (PBA-Gel). PEG-ZnO-sita, enabled by amidation, phenylboronic ester bonds, and metal-catechol coordination, confers rapid gelation, injectability, mechanical stability, self-healing, and robust tissue adhesion, adapting to the local complexity at the bone defect. In a diabetic microenvironment, the rapid breakage of boronate ester bonds triggers the early burst release of Zn
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