SynthesisBiology direct2026
Expression and mechanistic roles of long non-coding RNAs in diabetic cataract: a systematic review and meta-analysis.
Synthesis in Biology direct, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDiabetic cataract (DC) is a lens-opacity complication of diabetes driven by hyperglycemia-related oxidative, apoptotic, metabolic, and epithelial-mesenchymal transition (EMT) pathways. This review evaluated the expression and mechanistic roles of long non-coding RNAs (lncRNAs) and lncRNA-related epitranscriptomic regulators in DC.
methodsPubMed, Embase, Cochrane Library, Scopus, Web of Science, and Google Scholar were searched to 1 June 2026 without language restriction. Ex vivo, in vitro, transcriptomic, epitranscriptomic, and mechanistic studies were included. Two reviewers screened records, extracted data, and assessed bias using the JBI checklist. Random-effects meta-analysis pooled Fisher-z-transformed correlations; bias and certainty were assessed using funnel plot, exploratory Egger's test, and GRADE-adapted criteria.
resultsThirteen studies were included. Eight expression datasets showed a significant association between DC and lncRNA or lncRNA-linked epitranscriptomic dysregulation (pooled r = 0.445, 95% CI 0.338-0.541; p = 0.001), with low heterogeneity (I
conclusionDC is associated with coordinated lncRNA and epitranscriptomic dysregulation across oxidative, apoptotic, EMT, mitochondrial, proliferative, and m CLINICAL TRIAL NUMBER: Not applicable.
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