Sugar Amino Acid Linkers for the Design of [

Narendar R Gade, Melinda Wuest, Justin J Bailey, Atul Bhardwaj, Ralf Schirrmacher, Frank Wuest

Abstract read

In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Narendar R GadeDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0002-6786-2604

Melinda WuestDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.

Justin J BaileyDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0002-8280-5712

Atul BhardwajDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.

Ralf SchirrmacherDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0002-7098-3036

Frank WuestDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.ORCID https://orcid.org/0000-0002-6705-6450

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pronounced lipophilicity of tert-butyl-substituted silicon-fluoride-acceptor (SiFA) scaffolds represents a major limitation in radiotracer development, often resulting in elevated nonspecific uptake and reduced tumor-to-background ratios. To address this challenge, we designed and synthesized a series of prostate-specific membrane antigen (PSMA)-targeted radioligands incorporating furanose- and pyranose-based sugar amino acid (SAA) linkers to evaluate physicochemical properties while maintaining efficient

Indexed as

Amino AcidsAntigens, SurfaceDrug DesignFluoridesGlutamate Carboxypeptidase IIRadiopharmaceuticalsSiliconAnimalsCell Line, TumorFluorine RadioisotopesHumansLigandsMaleMiceMolecular StructurePositron-Emission TomographyAmino AcidsAntigens, SurfaceFluoridesFluorine-18Fluorine RadioisotopesFOLH1 protein, humanGlutamate Carboxypeptidase IILigandsRadiopharmaceuticalsSiliconfluorine‐18PET imagingprostate cancerPSMAsilicon‐fluoride‐acceptorsugar amino acids

Identifiers

PMID42587267

DOI10.1002/cmdc.70436

PMCPMC13469581

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.