Evidence map›Paper›PMID 42587162›Full record

ArticleNature2026

In vivo genome-wide CRISPR screens of human T cells in solid tumours.

Qi Liu, Peixin Amy Chen, Esha Urs, Shimin Zhang, Maya M Arce, Charlotte H Wang, Jun Yan, Vinh Q Nguyen, Zhongmei Li, Jin Seo and 23 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Engineering CAR-T cells to remodel the mucin-rich cancer cell glycocalyx.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Qi LiuDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA. qi.liu3@ucsf.edu.ORCID http://orcid.org/0009-0007-9410-2399
Peixin Amy ChenDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9930-1249
Esha UrsDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Shimin ZhangGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Maya M ArceDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Charlotte H WangDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7588-2077
Jun YanDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0005-9139-3966
Vinh Q NguyenDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Zhongmei LiDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Jin SeoDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Nupura KaleDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3185-8646
Fanglue PengDepartment of Microbiology and Immunology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA.
Yikai LuoDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7589-7981
Laine GoudyDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Taylor N LaFlamDepartment of Microbiology and Immunology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA.
Haixia ZhongDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Chandrima ModakGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Emma DannGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Jae Hyung JungDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.
Amanda KiraneDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, USA.
Allison Betof WarnerDivision of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Boi Bryant QuachDivision of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.
Zinaida GoodDivision of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2343-5771
Brian R ShyGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.
Eric ShifrutGray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Sagar P BapatWeill Cancer Hub West, Stanford University and University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-4402-1511
Greg M AllenDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0032-8140
Justin EyquemDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-8262-1190
Katherine FuhDepartment of OB/Gyn, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-7693-2694
Stacie E DodgsonGladstone-UCSF Institute of Genomic Immunology, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6622-5507
Jason G CysterDepartment of Microbiology and Immunology and Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5707-9256
Alexander MarsonDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2734-5776
Julia CarnevaleDepartment of Medicine, University of California San Francisco, San Francisco, CA, USA. julia.carnevale@ucsf.edu.ORCID http://orcid.org/0000-0001-9410-7148

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Large-scale CRISPR screening in human T cells holds significant promise for identifying genetic modifications that enhance cellular immunotherapy. Yet, many regulators of T cell performance in solid tumours are not revealed in vitro

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsGenome, HumanNeoplasmsT-LymphocytesAnimalsFemaleGene Knockout TechniquesGTP-Binding Protein alpha Subunits, GsHumansLymphocytes, Tumor-InfiltratingMaleMiceReceptors, G-Protein-CoupledSignal TransductionGTP-Binding Protein alpha Subunits, GsReceptors, G-Protein-Coupled

Identifiers

PMID42587162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.