ReviewNature2026
Shared principles of human and bacterial antiviral immunity.
Review in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Defence against viral infection is a conserved feature of all cellular life. From single-cell bacteria to humans and complex multicellular animals, constitutive and inducible forms of immunity are required to inhibit viruses and safeguard cellular fitness. Recent studies reveal that the components of human antiviral immunity are surprisingly ancient, originating billions of years ago in bacteria as pathways that defend against phage replication. The unification of previously disparate fields of human and bacterial immunity creates a foundation to explain key features of host-virus interactions. This Review defines principles of pathogen recognition, signal amplification and immune effector function that shape mechanisms of antiviral immunity that are shared across kingdoms of life. Shared forms of immunity, including cGAS-STING, inflammasomes, argonautes and viperin, reveal ancient features of antiviral defence. Similarly, direct comparisons of pattern recognition receptors and interferon-stimulated genes in human cells with CRISPR immunity and anti-phage defence systems in bacteria explain prevalent strategies to effectively sense and inhibit viral replication. Cross-kingdom analysis reveals universal rules that control host-virus interactions and highlights open questions in understanding of antiviral immunity.
Indexed as
Identifiers
42587116What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.