Evidence map›Paper›PMID 42587107›Full record

ArticleOncogene2026

Functional deficiency of circadian regulator PER2 enhances breast cancer susceptibility and progression with immunosuppression.

Yixin Duan, Aris T Alexandrou, Jie Huang, Helen S Zhang, Hongyong Zhang, Xiong Zhang, Dake Hao, Jonathan I Berg, Ming Fan, Yili Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yixin DuanDepartment of Radiation Oncology, University of California Davis, Sacramento, CA, USA. duanyixinn@163.com.
Aris T AlexandrouDepartment of Radiation Oncology, University of California Davis, Sacramento, CA, USA.
Jie HuangDepartment of Radiation Oncology, University of California Davis, Sacramento, CA, USA.ORCID http://orcid.org/0000-0003-0381-1549
Helen S ZhangDepartment of Radiation Oncology, University of California Davis, Sacramento, CA, USA.
Hongyong ZhangGenome Center, University of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0002-5669-5791
Xiong ZhangDepartment of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA, USA.
Dake HaoDepartment of Surgery, University of California Davis, Sacramento, CA, USA.
Jonathan I BergDepartment of Radiation Oncology, University of California Davis, Sacramento, CA, USA.
Ming FanDepartment of Radiation Oncology, University of California Davis, Sacramento, CA, USA.
Yili WangInstitute for Cancer Research, School of Basic Medical Science, Health Science Center of Xi'an Jiaotong University, Xi'an, China.
Loning FuDepartment of Medicine/MCB, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-7178-834X
Lunquan SunHunan Laboratory of Molecular Radiation Oncology, Xiangya Hospital, Central South University, Changsha, China.ORCID http://orcid.org/0000-0002-0558-5250
Jian Jian LiDepartment of Radiation Oncology, University of California Davis, Sacramento, CA, USA. jijli@ucdavis.edu.ORCID http://orcid.org/0000-0003-3694-9675

Funding

Mitochondrial bioenergetics is associated with aggressive breast cancer growthR01CA213830 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LI, JIAN JIAN · 2017 to 2021
$1.8M
NCI NIH HHS R01 CA213830U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) CA213830
6 · The paper itself

Abstract

Circadian rhythm (CR) governs systemic and tissue physiological homeostasis by regulating sleep-wake cycles, hormone secretion, and metabolism. CR disruption (CRD), such as shift work, has been associated with increased cancer risk, particularly female breast cancer (BC), yet the mechanisms underlying breast tumorigenesis and immunosuppression resulting from a specific clock gene dysfunction remain unclear. Here, we identify that circadian regulator Period 2 (PER2) is significantly downregulated in BC and correlates with poor prognosis. PER2 functional deficiency mice (PAS-B domain deletion, Per2

Indexed as

Breast NeoplasmsPeriod Circadian ProteinsAnimalsCircadian RhythmDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansImmune ToleranceMiceTumor MicroenvironmentPER2 protein, humanPer2 protein, mousePeriod Circadian Proteins

Identifiers

PMID42587107
PMCPMC13600920

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.