Evidence map›Paper›PMID 42587075›Full record

ArticleAnalytical and bioanalytical chemistry2026

Integrating liquid-liquid extraction and dispersive solid-phase extraction cleanup for high-throughput profiling of 11 neonicotinoids and 6 metabolites in human urine by HPLC-Q-Orbitrap HRMS.

Feng Liu, Decong Yu, Kun He, Yanan Song, Yichao Li, Haoxuan Gao, Bing Wu, Xiaoyu Li, Ji Zhao, Fei Xu and 1 more

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Feng LiuCollege of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, Ningxia, 750004, PR China.
Decong YuCollege of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, Ningxia, 750004, PR China.
Kun HeCollege of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, Ningxia, 750004, PR China.
Yanan SongCollege of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, Ningxia, 750004, PR China.
Yichao LiCollege of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, Ningxia, 750004, PR China.
Haoxuan GaoCollege of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, Ningxia, 750004, PR China.
Bing WuCollege of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, Ningxia, 750004, PR China.
Xiaoyu LiCollege of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, Ningxia, 750004, PR China.
Ji ZhaoCollege of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, Ningxia, 750004, PR China.
Fei XuPhysical and Chemical Department of Ningxia Center for Disease Control and Prevention, Yinchuan, Ningxia, 750004, PR China. xfcdc@nxmu.edu.cn.
Huifang YangCollege of Public Health, Ningxia Medical University, No. 1160, Shengli Street, Xingqing District, Yinchuan, Ningxia, 750004, PR China. 20040006@nxmu.edu.cn.

Funding

National Natural Science Foundation of China 82460635Natural Science Foundation of Ningxia Province 2026AAC030534Yinchuan Science and Technology Support Project of Ningxia Hui Autonomous Region 2024SF001
6 · The paper itself

Abstract

The widespread use of neonicotinoids has raised growing concerns about their potential health risks. In this study, we developed a robust and high-throughput analytical method based on liquid-liquid extraction (LLE) and dispersive solid-phase extraction (dSPE), followed by high-performance liquid chromatography-quadrupole-Orbitrap high-resolution mass spectrometry (HPLC-Q-Orbitrap HRMS) for the simultaneous determination of 11 neonicotinoids and their 6 metabolites in human urine. After pretreatment of LLE and dSPE, qualitative and confirmatory analysis was achieved using tMS

Indexed as

Dispersive solid-phase extractionHigh-performance liquid chromatography-Q-Orbitrap high resolution mass spectrometryLiquid-liquid extractionNeonicotinoidsUrine samples

Identifiers

PMID42587075

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.