Evidence map›Paper›PMID 42587040›Full record

ArticleExperimental & molecular medicine2026

Extinction-restraint intervention eradicates fear memory encoded in BLA engram cells via D2 receptor-mediated dopaminergic modulation from locus coeruleus.

Tongxia Li, Jian Yang, Chi Cui, Kun Ren, Lijun Zhang, Ming Li, Xueke Yang, Xiang Peng, Jie Lei, Yulong Shi and 8 more

Abstract read
In one paragraph

Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Tongxia Li *Hubei Provincial Clinical Research Center for Alzheimer's Disease, Tianyou Hospital, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Jian Yang *Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Chi CuiHubei Provincial Clinical Research Center for Alzheimer's Disease, Tianyou Hospital, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Kun RenDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Lijun ZhangDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Ming LiDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Xueke YangDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Xiang PengDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Jie LeiDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Yulong ShiDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Gangan LuoDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Yibo YaoDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Junsong DuDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Sitong ChenDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China.
Jie MingDepartment of Breast and Thyroid Surgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Xuemin WangDepartment of Neurobiology, Southern Medical University, Guangzhou, Guangdong Province, China. xmwang@smu.edu.cn.
Pei ZhangDepartment of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Provin, China. zhangpei@hust.edu.cn.ORCID http://orcid.org/0000-0003-0608-5677
Bo TianHubei Provincial Clinical Research Center for Alzheimer's Disease, Tianyou Hospital, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China. tianbo@wust.edu.cn.

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32271036National Natural Science Foundation of China (National Science Foundation of China) 32571176
6 · The paper itself

Abstract

Despite undergoing exposure therapy, individuals with post-traumatic stress disorder (PTSD) frequently experience relapses when confronted with trauma reminders. This study examined the impact of extinction-restraint intervention (Ext-Res) in a PTSD-related fear relapse model. We found that reactivation of basolateral amygdala engram cells (BLA

Indexed as

Basolateral Nuclear ComplexDopamineExtinction, PsychologicalFearLocus CoeruleusMemoryReceptors, Dopamine D2AnimalsMaleMiceRestraint, PhysicalStress Disorders, Post-TraumaticDopamineReceptors, Dopamine D2

Identifiers

PMID42587040
PMCPMC13538692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.