ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026
Paternal epigenetic inheritance increases susceptibility to methamphetamine taking.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
13 authors.
Funding
Abstract
We previously demonstrated that male progeny of cocaine-experienced sires resisted cocaine, expressed as delayed acquisition of cocaine self-administration. Here, we sought to determine whether this phenotype extended to another psychostimulant, methamphetamine (meth). Sires self-administered meth or cocaine or received yoked-saline infusions for 60 days, after which they were mated to naïve females. Some behaviors previously altered in cocaine-sired male rats, including object memory and anxiety-like behavior, were not influenced by paternal meth taking. In contrast to cocaine resistance in cocaine-sired male rats, meth-sired male offspring demonstrated increased susceptibility to meth taking, with no effect in females. Single nuclei RNA- and ATAC-sequencing of the nucleus accumbens was used to identify molecular drivers of phenotypes in cocaine- and meth-sired offspring. Sequencing results revealed unique profiles of gene expression and open chromatin in offspring nucleus accumbens. Differential gene expression in cocaine-resistant, cocaine-sired offspring and meth-susceptible, meth-sired offspring illuminates potential novel treatment targets for psychostimulant use disorders.
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Registered trials
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