Reviewnpj biomedical innovations2026
Crosstalk-free optical indicator-actuator combinations for bidirectional optogenetics.
Review in npj biomedical innovations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
Abstract
Bidirectional optogenetics enables simultaneous optical readout and manipulation of neural activity. However, optical crosstalk between actuators and indicators impedes clean observation and control. This review surveys genetically encoded indicators and optogenetic actuators, and the mechanisms of crosstalk, then catalogues reported crosstalk-free pairings and trade-offs. Finally, we propose best-practice guidelines and identify future directions, including near-infra-red and two-photon modalities, protein engineering and computational correction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.