ArticleScientific reports2026
Possible relationship between genetic polymorphisms and the risk of exercise addiction among Turkish elite athletes: an exploratory pilot study.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Exercise addiction (EA) is a complex behavioral phenotype characterized by a loss of control over exercise despite adverse physical, psychological, and social consequences. Although its psychological and performance-related aspects have been widely studied, its underlying etiology remains largely unclear, leading to increased interest in potential genetic vulnerability. Therefore, an exploratory pilot study investigated genetic variants associated with EA among elite athletes using a genome-wide association study (GWAS). The study comprised 168 Turkish elite athletes. Allele frequencies of critical single-nucleotide polymorphisms (SNPs) were further assessed among a comparison group of 5137 healthy individuals using data from a publicly available database. EA was assessed using the Exercise Addiction Inventory. Genome-wide genotyping was conducted using a DNA microarray, and associations were examined using linear mixed models adjusted for sport discipline, sex, age, and training experience. Although no variants reached genome-wide significance (p < 1.11 × 10
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