Evidence map›Paper›PMID 42587007›Full record

ArticleCell death and differentiation2026

Spatial and functional characterization of ER stress proteins links fibroblast plasticity and proliferative processes in human osteoarthritic synovitis.

Zoé Gendebien, Christophe Poulet, Céline Deroyer, Geneviève Paulissen, Pauline Salpetier, Alexandre Hego, Gaëtan Lefèvre, Gaël Cobraiville, Sophie Neuville, Zelda Plener and 11 more

Abstract read
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Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Zoé GendebienLaboratory of Rheumatology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
Christophe PouletLaboratory of Rheumatology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0003-4055-5441
Céline DeroyerLaboratory of Rheumatology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.ORCID http://orcid.org/0000-0002-5399-0891
Geneviève PaulissenLaboratory of Rheumatology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
Pauline SalpetierLaboratory of Rheumatology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
Alexandre HegoGIGA Cell Imaging, University of Liège, Liège, Belgium.ORCID http://orcid.org/0009-0007-7968-6795
Gaëtan LefèvreGIGA Cell Imaging, University of Liège, Liège, Belgium.
Gaël CobraivilleLaboratory of Rheumatology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
Sophie NeuvilleLaboratory of Rheumatology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
Zelda PlenerLaboratory of Rheumatology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
Christophe DanielOrthopedic Surgery Department, Centre Hospitalier Universitaire de Liège, Liège, Belgium.
Thierry ThirionOrthopedic Surgery Department, Centre Hospitalier Universitaire de Liège, Liège, Belgium.
Tatiana SokolovaDivision of Systemic and Inflammatory Rheumatic Diseases, Institute of Experimental and Clinical Research, Catholic University of Louvain, Brussels, Belgium.
Patrick DurezDivision of Systemic and Inflammatory Rheumatic Diseases, Institute of Experimental and Clinical Research, Catholic University of Louvain, Brussels, Belgium.
Patrice HemonLBAI, UMR1227, Univ Brest, Inserm, Brest, France.ORCID http://orcid.org/0000-0002-2244-5321
Yuna DelarueLBAI, UMR1227, Univ Brest, Inserm, Brest, France.
Nadège MarecLBAI, UMR1227, Univ Brest, Inserm, Brest, France.
Elettra BianchiDepartment of Pathology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
Philippe DelvenneDepartment of Pathology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
Clio RibbensLaboratory of Rheumatology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.
Dominique de SenyLaboratory of Rheumatology, GIGA Research Center, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium. ddeseny@chuliege.be.ORCID http://orcid.org/0000-0002-5757-9418

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A strong crosstalk exists between endoplasmic reticulum (ER) stress and synovitis. Beyond their canonical role in protein folding, ER stress chaperones may promote inflammation, cell survival, and fibroblast activation under pathological conditions. This study aimed at localizing and quantifying 11 ER stress proteins (BiP, HYOU1, MANF, PDIA4, GANAB, HSP90B1, TXNDC5, DNAJB11, LMAN1, ERP29, CALR) in human inflamed synovial membranes and at investigating their expression in fibroblast-like synoviocytes (FLS) under ER stress, pro-inflammatory, or pro-fibrotic stimuli. By immunohistochemistry, on a first cohort of formalin-fixed paraffin-embedded (FFPE) biopsies obtained from patients with osteoarthritis (OA), chronic pyrophosphate arthropathy (CPPA), and rheumatoid arthritis (RA), these ER chaperones were primarily localized to the lining in low-grade inflammation (Tak <4) and expanded to the sublining under high inflammatory conditions (Tak ≥4), with a widespread distribution in RA. Imaging mass cytometry, applied to a second cohort of FFPE tissue samples collected from patients diagnosed with OA and RA, revealed the co-expression of ER stress proteins with CD55⁺ FLS in the lining and their progressive infiltration into the sublining along with CD34⁺CD31

Identifiers

PMID42587007

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.