Evidence map›Paper›PMID 42586758›Full record

ArticleGenes & development2026

Differential control of both cell cycle-regulated and quantitative histone mRNA expression by

Mark S Geisler, James P Kemp, Christina A Hill, William F Marzluff, Robert J Duronio

Abstract read
PubMed Publisher
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Mark S GeislerCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.ORCID http://orcid.org/0000-0002-2900-4609
James P KempIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA.ORCID http://orcid.org/0000-0003-1975-1149
Christina A HillIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
William F MarzluffCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA.ORCID http://orcid.org/0000-0003-3635-4073
Robert J DuronioCurriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA; duronio@med.unc.edu.ORCID http://orcid.org/0000-0001-6469-6965

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coupling histone gene expression to S phase of the cell cycle is essential for genome duplication and stability. Activation of Cyclin E/Cdk2 at the G1-S transition stimulates high-level expression of histone genes during S phase, but how histone genes are turned off at the end of S phase is not understood. Here we demonstrate that the essential

Indexed as

Cell CycleDrosophila melanogasterDrosophila ProteinsGene Expression Regulation, DevelopmentalHistonesAnimalsCyclin-Dependent Kinase 2Cyclin EPhosphorylationRNA, MessengerTumor Suppressor ProteinsCyclin-Dependent Kinase 2Cyclin EDrosophila ProteinsHistonesMxc protein, DrosophilaRNA, MessengerTumor Suppressor Proteinsbiomolecular condensatescell cycleDrosophilahistonestranscription

Identifiers

PMID42586758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.