ArticleClinical obesity2026
Re: Aerobic Exercise Plus Hypocaloric Diet on Serum Leptin Concentrations in Adults With Primary Hypertension and Overweight/Obesity: Results From the EXERDIET-HTA Trial.
Article in Clinical obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
This correspondence addresses the EXERDIET-HTA substudy by Aparicio and colleagues, which concludes that 16 weeks of aerobic exercise plus a hypocaloric DASH diet reduced serum leptin more than diet with activity counselling in hypertensive adults with overweight or obesity. Five concerns are raised: inference from within-group p values despite a non-significant time × group interaction; pooling of three sub-threshold exercise protocols; mislabelling of an active comparator as 'attention control'; sevenfold attrition asymmetry analysed by complete-case rather than intention-to-treat methods; and effectively complete reversion of leptin at 6 months. A disaggregated, ITT re-analysis would yield more conservative but more defensible conclusions.
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