Evidence map›Paper›PMID 42586564›Full record

ArticlePediatrics2026

Discretionary Child Protective Services Reporting for Infants With Prenatal Opioid Exposure.

Rohan Khazanchi, Davida M Schiff, Elizabeth Egan, Genevieve Preer, Paul R Shafer, Kirsten Austad, Cecily M Barber, Mei Elansary, Raquel Selcer, Kaye-Alese Green and 4 more

Abstract read
In one paragraph

Article in Pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rohan KhazanchiDivisions of Health Policy & Insurance Research (HPI) and Child Health Research & Policy (CHeRP), Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Healthcare Institute, Boston, Massachusetts.
Davida M SchiffDivision of General Academic Pediatrics, Mass General Brigham for Children, Boston, Massachusetts.
Elizabeth EganDepartment of Pediatrics, Boston Medical Center, Boston, Massachusetts.
Genevieve PreerDepartment of Pediatrics, Boston Medical Center, Boston, Massachusetts.
Paul R ShaferDepartment of Health, Law, Policy, and Management, School of Public Health, Boston University, Boston, Massachusetts.
Kirsten AustadDepartment of Family Medicine, Boston University Chobanian & Avedisian School of Medicine and Boston Medical Center, Boston, Massachusetts.
Cecily M BarberDepartment of Obstetrics and Gynecology, Boston Medical Center, Boston, Massachusetts.
Mei ElansaryDepartment of Pediatrics, Boston Medical Center, Boston, Massachusetts.
Raquel SelcerDepartment of Pediatrics, Boston Medical Center, Boston, Massachusetts.
Kaye-Alese GreenDepartment of Pediatrics, Boston Medical Center, Boston, Massachusetts.
Tobi OkopieDepartment of Pediatrics, Boston Medical Center, Boston, Massachusetts.
Anna M ModestDepartment of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Elisha M WachmanDepartment of Pediatrics, Boston Medical Center, Boston, Massachusetts.
Heather E HsuDepartment of Pediatrics, Boston Medical Center, Boston, Massachusetts.

Funding

Improving Treatment Engagement and Adherence to Optimize Outcomes for Opioid-Exposed Mother-Infant DyadsK23DA048169 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI SCHIFF, DAVIDA · 2019 to 2023
$998k
Improving value-based healthcare delivery for opioid use disorderK01DA054328 · NIDA · BOSTON MEDICAL CENTER · PI HSU, HEATHER · 2021 to 2025
$897k
Adapting an Evidence-Based Intervention to Improve the Hospital Discharge Process for Patients with Limited English ProficiencyK23MD019068 · NIMHD · BOSTON MEDICAL CENTER · PI Kirsten Austad · 2023 to 2026
$648k
Promoting positive parenting for mothers with OUD: Implementation of a video-coaching intervention in pediatricsK23DA061933 · NIDA · BOSTON MEDICAL CENTER · PI Mei Elansary · 2025 to 2026
$387k
NIDA NIH HHS K01 DA054328NIDA NIH HHS K23 DA048169NIDA NIH HHS K23 DA061933NIMHD NIH HHS K23 MD019068
6 · The paper itself

Abstract

objectiveHospital guidelines implemented in May 2021 to end reflexive child protective services (CPS) reporting for infants with prenatal substance exposure nearly halved overall reporting rates among infants with prenatal opioid exposure (IPOE). Given concerns that discretionary reporting may exacerbate inequities, this study assessed whether the guideline's effects differed between subgroups of IPOEs.

methodsWe used a difference-in-difference-in-differences (DDD) approach to assess the differential impact of guideline implementation on rates of CPS reporting and discharge in the custody of a biological parent by minoritized (vs nonminoritized) birthing parent race and ethnicity, prescribed (vs any nonprescribed) opioid exposure, and presence (vs absence) of additional nonopioid coexposures. Analyses included 3581 IPOEs born across 17 Massachusetts birthing hospitals from 2017 to 2024.

resultsIn DDD analyses, guideline implementation did not differentially affect rates of CPS reporting by race and ethnicity or coexposure to cannabis. Guideline implementation did lead to larger decreases in CPS reporting rates among IPOEs exposed to only prescribed opioids compared with those exposed to nonprescribed opioids (DDD, -61.3 percentage points [pp] [95% CI, -65.6 to -57.0]), as well as larger decreases among IPOEs without additional exposures to alcohol (-27.1 pp [-37.0 to -17.2]), amphetamines (-17.7 pp [-27.7 to -7.8]), benzodiazepines (-16.4 pp [-26.4 to -6.4]), and cocaine (-55.5 pp [-64.2 to -46.8]). Guideline implementation had no overall or differential impacts on rates of discharge in parental custody.

conclusionGuideline-informed discretionary reporting for IPOEs did not lead to differential impacts by race or ethnicity. The largest decreases in reporting were among infants with only prescribed opioid exposure and without other substance coexposures.

Indexed as

Analgesics, OpioidChild Protective ServicesPrenatal Exposure Delayed EffectsFemaleHumansInfantInfant, NewbornMaleMassachusettsPractice Guidelines as TopicPregnancyAnalgesics, Opioid

Identifiers

PMID42586564
PMCPMC13588230

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.