ArticleCell reports. Medicine2026
Preclinical evaluation of nitrated α-synuclein-specific CAR-Treg therapy in Parkinson's disease.
Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current evidence indicates that Parkinson's disease (PD) involves T cell-mediated inflammation, which plays a fundamental role in promoting neuroinflammation and neurodegeneration in patients and animal models. These T cells are specific to α-synuclein-derived antigens, including nitrated α-synuclein (NαSyn). Here, we sought to develop an experimental immunotherapy for PD based on the generation of regulatory T cells (Treg) specific to NαSyn, using the chimeric antigen receptor (CAR) technology. Accordingly, we first obtained an antibody specific to human α-synuclein containing three nitrated tyrosine residues (3NY-hαSyn), which displayed specific immunoreactivity in the serum of PD patients which correlated with the clinical score. Afterward, we generated CAR-Treg specific to 3NY-hαSyn and tested them in two PD models involving human α-synuclein. The CAR-Treg therapy substantially inhibited the inflammatory T cell response specific to α-synuclein-derived antigens, neuroinflammation, neurodegeneration, and the motor decline. This preclinical study indicates that the CAR-Treg therapy represents a promising therapeutic strategy for treating PD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.