Evidence map›Paper›PMID 42585825›Full record

ArticleJournal of psychiatric research2026

Measuring psychomotor agitation via hand tremor in remitted major depressive disorder.

Megan E McFarland, Stewart A Shankman, James E Glazer, David M Klemballa, Sebastian Walther, Vijay A Mittal, Brent I Rappaport

Abstract read
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In one paragraph

Article in Journal of psychiatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Megan E McFarlandStephen M. Stahl Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA; Department of Psychology, University of Miami, Coral Gables, FL, USA.
Stewart A ShankmanStephen M. Stahl Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA; Department of Psychology, Northwestern University, Evanston, IL, USA.
James E GlazerStephen M. Stahl Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA.
David M KlemballaStephen M. Stahl Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA.
Sebastian WaltherTranslational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Switzerland; Department of Psychiatry, Psychosomatics, and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
Vijay A MittalDepartment of Psychology, Northwestern University, Evanston, IL, USA.
Brent I RappaportStephen M. Stahl Center for Psychiatric Neuroscience, Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA. Electronic address: brent.rappaport@northwestern.edu.

Funding

An examination of psychomotor disturbance in current and remitted MDD: An RDoC StudyR01MH118741 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MITTAL, VIJAY A, SHANKMAN, STEWART AARON · 2019 to 2023
$3.4M
NUCATS T32T32TR005124 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Jacqueline Katrina Gollan, Susanna A McColley · 2024 to 2026
$1.1M
Computational Modeling of Ambiguity Aversion in Internalizing Disorders: Neural and Behavioral Markers, and a Test of Target EngagementK23MH136421 · NIMH · NORTHWESTERN UNIVERSITY · PI Brent Ian Rappaport · 2025 to 2026
$382k
NCATS NIH HHS T32 TR005124NIMH NIH HHS K23 MH136421NIMH NIH HHS R01 MH118741
6 · The paper itself

Abstract

Psychomotor agitation (PmA), a common yet understudied symptom in Major Depressive Disorder (MDD), is characterized by heightened motor activity such as restlessness and fidgeting. PmA, like other symptoms of MDD, may persist into remission. This study examined the role of PmA in remitted MDD by using a novel smartphone based physiological measure of tremor. Participants (N = 157) consisted of healthy controls (N = 76) and those with remitted MDD (N = 81, to reduce the impact of current MDD symptoms on PmA), and tremor was assessed under the manipulation of position (palm-up, arm extended) and cognitive load (no cognitive load, cognitive load). Individuals with remitted-MDD exhibited a distinct pattern from HCs: specifically, greater tremor under high cognitive load compared to no cognitive load, while HCs showed lower tremor under cognitive load compared to no cognitive load. These findings suggest that tremor is sensitive to cognitive demands, and that tremor may provide an objective, physiological marker of PmA in remitted MDD. More generally, our results highlight the importance of using instrumental measures to assess PmA.

Indexed as

HandMajor Depressive DisorderPsychomotor AgitationTremorAdultFemaleHumansMaleMiddle AgedDepressionInstrumental measuresPsychomotor agitationtremor

Identifiers

PMID42585825
PMCPMC13551586

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.