ArticleNeurology2026
Intervention or Conservative Management for Symptomatic Cerebral Cavernous Malformations: A Prospective, Population-Based Cohort Study.
Article in Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
BACKGROUND AND
objectivesThere is ongoing clinical equipoise regarding the optimal treatment strategy for symptomatic cerebral cavernous malformations (CCMs). The aim of this study was to estimate the causal effect between CCM intervention (microsurgical resection or stereotactic radiosurgery) and clinical outcomes during long-term follow-up.
methodsThis population-based cohort study included patients (aged 16 years or older) newly diagnosed with CCM using brain MRI or pathology in Scotland during 1999-2003 or 2006-2010. Using Cox regression analysis, we evaluated associations between CCM intervention (as a time-dependent covariate) and a primary outcome of persistent functional impairment or death (defined as at least 2 consecutive annual Oxford Handicap Scale [OHS] scores of ≥2, with sensitivity analysis of OHS scores ≥3), a composite of symptomatic intracranial hemorrhage or new persistent/progressive nonhemorrhagic focal neurologic deficit (ICH/FND) definitely/possibly related to CCM or CCM intervention, and epileptic seizure(s) definitely/possibly related to CCM during prospective follow-up.
resultsAmong 306 patients with CCM, 190 were symptomatic (89 [47%] because of ICH/FND and 101 [53%] because of epileptic seizure(s), median age 40 years [interquartile range (IQR) 31-55], and 95 [50%] women). During a median follow-up of 16 years (IQR 14-21, completeness 95%), 37 (19%) patients underwent CCM intervention (n = 35 microsurgical resection and n = 2 stereotactic radiosurgery); they were younger (median 33 [26-40] vs 43 [32-59] years, DISCUSSION: CCM intervention for symptomatic CCM was associated with persistent functional dependence or death during long-term follow-up. This may be explained by ICH/FND definitely related to CCM or CCM intervention. These findings should be investigated in a definitive randomized controlled trial.
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