Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
12 authors.
Rendan YangShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Reproductive Medicine Center, Zhongshan Hospital, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, China.ORCID 0000-0001-5923-0378
Yu SunShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Reproductive Medicine Center, Zhongshan Hospital, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, China.ORCID 0000-0003-2392-2043
Wenzheng WangShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Reproductive Medicine Center, Zhongshan Hospital, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, China.ORCID 0009-0006-1374-8503
Yuxuan LeiShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Reproductive Medicine Center, Zhongshan Hospital, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, China.ORCID 0009-0004-7590-444X
Lin ChenShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Reproductive Medicine Center, Zhongshan Hospital, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, China.ORCID 0009-0007-8200-7837
Xiaoxu LiLaboratory of Integrative Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0001-5121-9190
Raya B LiuShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Reproductive Medicine Center, Zhongshan Hospital, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, China.ORCID 0009-0006-1767-3385
Ang ZhouShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Reproductive Medicine Center, Zhongshan Hospital, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, China.ORCID 0009-0000-3592-2433
Arwen W GaoLaboratory of Integrative Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0001-7687-8926
Liangshan MuReproductive Medicine Center, Zhongshan Hospital, Fudan University, Shanghai, China.ORCID 0000-0003-2498-3825
Johan AuwerxLaboratory of Integrative Systems Physiology, Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.ORCID 0000-0002-5065-5393
Terytty Yang LiShanghai Key Laboratory of Metabolic Remodeling and Health, Institute of Metabolism and Integrative Biology, Reproductive Medicine Center, Zhongshan Hospital, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, Fudan University, Shanghai, China.ORCID 0000-0003-3684-7935
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Mild mitochondrial stress could extend lifespan across species, yet the underlying mechanism remains unclear. Here, we show that inhibition of mitochondrial respiration induces a sustained transcriptional program that enhances lysosomal proteolysis during aging in
Indexed as
Caenorhabditis elegansCaenorhabditis elegans ProteinsGATA Transcription FactorsLongevityLysosomesMitochondriaProteostasisStress, PhysiologicalAnimalsPeptidesProteotoxic StressUnfolded Protein ResponseCaenorhabditis elegans ProteinsELT-2 protein, C elegansGATA Transcription FactorsPeptidespolyglutamine
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Mitochondrial stress activates ELT-2-dependent lysosomal proteostasis to extend lifespan in · full record | OpenQuestion